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Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19

BACKGROUND: Coronavirus disease (COVID-19) has resulted in considerable morbidity and mortality worldwide. Thyroid hormones play a key role in modulating metabolism and the immune system. However, the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19 have not...

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Autores principales: Zhang, Yan, Lin, Fengyu, Tu, Wei, Zhang, Jianchu, Choudhry, Abira Afzal, Ahmed, Omair, Cheng, Jun, Cui, Yanhui, Liu, Ben, Dai, Minhui, Chen, Lingli, Han, Duoduo, Fan, Yifei, Zeng, Yanjun, Li, Wen, Li, Sha, Chen, Xiang, Shen, Minxue, Pan, Pinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709789/
https://www.ncbi.nlm.nih.gov/pubmed/33278491
http://dx.doi.org/10.1016/j.mce.2020.111097
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author Zhang, Yan
Lin, Fengyu
Tu, Wei
Zhang, Jianchu
Choudhry, Abira Afzal
Ahmed, Omair
Cheng, Jun
Cui, Yanhui
Liu, Ben
Dai, Minhui
Chen, Lingli
Han, Duoduo
Fan, Yifei
Zeng, Yanjun
Li, Wen
Li, Sha
Chen, Xiang
Shen, Minxue
Pan, Pinhua
author_facet Zhang, Yan
Lin, Fengyu
Tu, Wei
Zhang, Jianchu
Choudhry, Abira Afzal
Ahmed, Omair
Cheng, Jun
Cui, Yanhui
Liu, Ben
Dai, Minhui
Chen, Lingli
Han, Duoduo
Fan, Yifei
Zeng, Yanjun
Li, Wen
Li, Sha
Chen, Xiang
Shen, Minxue
Pan, Pinhua
author_sort Zhang, Yan
collection PubMed
description BACKGROUND: Coronavirus disease (COVID-19) has resulted in considerable morbidity and mortality worldwide. Thyroid hormones play a key role in modulating metabolism and the immune system. However, the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19 have not yet been elucidated. In this study, we seek to address this gap and understand the link between TD and COVID-19. METHODS: Herein, we enrolled patients who were hospitalized with COVID-19 and had normal or abnormal thyroid function test results at the West Court of Union Hospital in Wuhan, China, between 29 January and February 26, 2020. We carried out follow up examinations until April 26, 2020. Data on clinical features, treatment strategies, and prognosis were collected and analyzed. TD was defined as an abnormal thyroid function test result, including overt thyrotoxicosis, overt hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism, and euthyroid sick syndrome. RESULTS: A total of 25 and 46 COVID-19 patients with and without TD, respectively, were included in the study. COVID-19 patients with TD had significantly higher neutrophil counts and higher levels of C-reactive protein, procalcitonin, lactate dehydrogenase, serum creatine kinase, aspartate transaminase, and high-sensitive troponin I and a longer activated partial thromboplastin time but lower lymphocyte, platelet, and eosinophil counts. A longitudinal analysis of serum biomarkers showed that patients with TD presented persistently high levels of biomarkers for inflammatory response and cardiac injury. COVID-19 patients with TD were more likely to develop a critical subtype of the disease. Patients with TD had a significantly higher fatality rate than did those without TD during hospitalization (20% vs 0%, P = 0.002). Patients with TD were more likely to stay in the hospital for more than 28 days than were those without TD (80% vs 56.52%, P = 0.048). CONCLUSIONS: Our preliminary findings suggest that TD is associated with poor outcomes in patients with COVID-19.
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spelling pubmed-77097892020-12-03 Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19 Zhang, Yan Lin, Fengyu Tu, Wei Zhang, Jianchu Choudhry, Abira Afzal Ahmed, Omair Cheng, Jun Cui, Yanhui Liu, Ben Dai, Minhui Chen, Lingli Han, Duoduo Fan, Yifei Zeng, Yanjun Li, Wen Li, Sha Chen, Xiang Shen, Minxue Pan, Pinhua Mol Cell Endocrinol Article BACKGROUND: Coronavirus disease (COVID-19) has resulted in considerable morbidity and mortality worldwide. Thyroid hormones play a key role in modulating metabolism and the immune system. However, the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19 have not yet been elucidated. In this study, we seek to address this gap and understand the link between TD and COVID-19. METHODS: Herein, we enrolled patients who were hospitalized with COVID-19 and had normal or abnormal thyroid function test results at the West Court of Union Hospital in Wuhan, China, between 29 January and February 26, 2020. We carried out follow up examinations until April 26, 2020. Data on clinical features, treatment strategies, and prognosis were collected and analyzed. TD was defined as an abnormal thyroid function test result, including overt thyrotoxicosis, overt hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism, and euthyroid sick syndrome. RESULTS: A total of 25 and 46 COVID-19 patients with and without TD, respectively, were included in the study. COVID-19 patients with TD had significantly higher neutrophil counts and higher levels of C-reactive protein, procalcitonin, lactate dehydrogenase, serum creatine kinase, aspartate transaminase, and high-sensitive troponin I and a longer activated partial thromboplastin time but lower lymphocyte, platelet, and eosinophil counts. A longitudinal analysis of serum biomarkers showed that patients with TD presented persistently high levels of biomarkers for inflammatory response and cardiac injury. COVID-19 patients with TD were more likely to develop a critical subtype of the disease. Patients with TD had a significantly higher fatality rate than did those without TD during hospitalization (20% vs 0%, P = 0.002). Patients with TD were more likely to stay in the hospital for more than 28 days than were those without TD (80% vs 56.52%, P = 0.048). CONCLUSIONS: Our preliminary findings suggest that TD is associated with poor outcomes in patients with COVID-19. Elsevier B.V. 2021-02-05 2020-12-02 /pmc/articles/PMC7709789/ /pubmed/33278491 http://dx.doi.org/10.1016/j.mce.2020.111097 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Yan
Lin, Fengyu
Tu, Wei
Zhang, Jianchu
Choudhry, Abira Afzal
Ahmed, Omair
Cheng, Jun
Cui, Yanhui
Liu, Ben
Dai, Minhui
Chen, Lingli
Han, Duoduo
Fan, Yifei
Zeng, Yanjun
Li, Wen
Li, Sha
Chen, Xiang
Shen, Minxue
Pan, Pinhua
Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title_full Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title_fullStr Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title_full_unstemmed Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title_short Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19
title_sort thyroid dysfunction may be associated with poor outcomes in patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709789/
https://www.ncbi.nlm.nih.gov/pubmed/33278491
http://dx.doi.org/10.1016/j.mce.2020.111097
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