Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature. Here, we use genome sequencing to characterize mutations in yea...

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Detalles Bibliográficos
Autores principales: Laughery, Marian F., Brown, Alexander J., Bohm, Kaitlynne A., Sivapragasam, Smitha, Morris, Haley S., Tchmola, Mila, Washington, Angelica D., Mitchell, Debra, Mather, Stephen, Malc, Ewa P., Mieczkowski, Piotr A., Roberts, Steven A., Wyrick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709870/
https://www.ncbi.nlm.nih.gov/pubmed/33207206
http://dx.doi.org/10.1016/j.celrep.2020.108401

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