Enhanced Protein Damage Clearance Induces Broad Drug Resistance in Multitype of Cancers Revealed by an Evolution Drug‐Resistant Model and Genome‐Wide siRNA Screening

Resistance to therapeutic drugs occurs in virtually all types of cancers, and the tolerance to one drug frequently becomes broad therapy resistance; however, the underlying mechanism remains elusive. Combining a whole whole‐genome‐wide RNA interference screening and an evolutionary drug pressure mod...

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Detalles Bibliográficos
Autores principales: Shao, Fangyuan, Lyu, Xueying, Miao, Kai, Xie, Lisi, Wang, Haitao, Xiao, Hao, Li, Jie, Chen, Qiang, Ding, Renbo, Chen, Ping, Xing, Fuqiang, Zhang, Xu, Luo, Guang‐Hui, Zhu, Wenli, Cheng, Gregory, Lon, Ng Wai, Martin, Scott E., Wang, Guanyu, Chen, Guokai, Dai, Yunlu, Deng, Chu‐Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709997/
https://www.ncbi.nlm.nih.gov/pubmed/33304752
http://dx.doi.org/10.1002/advs.202001914

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