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Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis

Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the asso...

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Autores principales: Rehm, Martin, Büchele, Gisela, Peter, Raphael Simon, Brenner, Rolf Erwin, Günther, Klaus-Peter, Brenner, Hermann, Koenig, Wolfgang, Rothenbacher, Dietrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710029/
https://www.ncbi.nlm.nih.gov/pubmed/33264342
http://dx.doi.org/10.1371/journal.pone.0242814
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author Rehm, Martin
Büchele, Gisela
Peter, Raphael Simon
Brenner, Rolf Erwin
Günther, Klaus-Peter
Brenner, Hermann
Koenig, Wolfgang
Rothenbacher, Dietrich
author_facet Rehm, Martin
Büchele, Gisela
Peter, Raphael Simon
Brenner, Rolf Erwin
Günther, Klaus-Peter
Brenner, Hermann
Koenig, Wolfgang
Rothenbacher, Dietrich
author_sort Rehm, Martin
collection PubMed
description Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years. During a median follow-up of 18.4 years, 332 (48.9%) subjects died. Median of hs-cTnT, hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L, and 96.8 ng/L. The top quartile of NT-proBNP was associated with increased risk of mortality (Hazard Ratio (HR) 1.79, 95% confidence interval (CI) 1.17–2.73) after adjustment for covariates including troponins (hs-cTnT HR 1.30 (95% CI 0.90–1.89), hs-cTnI HR 1.32 (95% CI 0.87–2.00) for top category). When biomarker associations were evaluated as continuous variables, only NT-proBNP (HR per log-unit increment 1.34, 95% CI 1.16–1.54) and hs-cTnI (HR 1.38, 95% CI 1.11–1.72) showed robust results. Elevated cardiac biomarker concentrations predicted an increased risk of long-term mortality and strongest for NT-proBNP and hs-cTnI. These results might help to identify subjects at risk and target preventive efforts early.
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spelling pubmed-77100292020-12-03 Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis Rehm, Martin Büchele, Gisela Peter, Raphael Simon Brenner, Rolf Erwin Günther, Klaus-Peter Brenner, Hermann Koenig, Wolfgang Rothenbacher, Dietrich PLoS One Research Article Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years. During a median follow-up of 18.4 years, 332 (48.9%) subjects died. Median of hs-cTnT, hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L, and 96.8 ng/L. The top quartile of NT-proBNP was associated with increased risk of mortality (Hazard Ratio (HR) 1.79, 95% confidence interval (CI) 1.17–2.73) after adjustment for covariates including troponins (hs-cTnT HR 1.30 (95% CI 0.90–1.89), hs-cTnI HR 1.32 (95% CI 0.87–2.00) for top category). When biomarker associations were evaluated as continuous variables, only NT-proBNP (HR per log-unit increment 1.34, 95% CI 1.16–1.54) and hs-cTnI (HR 1.38, 95% CI 1.11–1.72) showed robust results. Elevated cardiac biomarker concentrations predicted an increased risk of long-term mortality and strongest for NT-proBNP and hs-cTnI. These results might help to identify subjects at risk and target preventive efforts early. Public Library of Science 2020-12-02 /pmc/articles/PMC7710029/ /pubmed/33264342 http://dx.doi.org/10.1371/journal.pone.0242814 Text en © 2020 Rehm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rehm, Martin
Büchele, Gisela
Peter, Raphael Simon
Brenner, Rolf Erwin
Günther, Klaus-Peter
Brenner, Hermann
Koenig, Wolfgang
Rothenbacher, Dietrich
Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title_full Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title_fullStr Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title_full_unstemmed Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title_short Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
title_sort relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710029/
https://www.ncbi.nlm.nih.gov/pubmed/33264342
http://dx.doi.org/10.1371/journal.pone.0242814
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