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Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis
Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the asso...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710029/ https://www.ncbi.nlm.nih.gov/pubmed/33264342 http://dx.doi.org/10.1371/journal.pone.0242814 |
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author | Rehm, Martin Büchele, Gisela Peter, Raphael Simon Brenner, Rolf Erwin Günther, Klaus-Peter Brenner, Hermann Koenig, Wolfgang Rothenbacher, Dietrich |
author_facet | Rehm, Martin Büchele, Gisela Peter, Raphael Simon Brenner, Rolf Erwin Günther, Klaus-Peter Brenner, Hermann Koenig, Wolfgang Rothenbacher, Dietrich |
author_sort | Rehm, Martin |
collection | PubMed |
description | Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years. During a median follow-up of 18.4 years, 332 (48.9%) subjects died. Median of hs-cTnT, hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L, and 96.8 ng/L. The top quartile of NT-proBNP was associated with increased risk of mortality (Hazard Ratio (HR) 1.79, 95% confidence interval (CI) 1.17–2.73) after adjustment for covariates including troponins (hs-cTnT HR 1.30 (95% CI 0.90–1.89), hs-cTnI HR 1.32 (95% CI 0.87–2.00) for top category). When biomarker associations were evaluated as continuous variables, only NT-proBNP (HR per log-unit increment 1.34, 95% CI 1.16–1.54) and hs-cTnI (HR 1.38, 95% CI 1.11–1.72) showed robust results. Elevated cardiac biomarker concentrations predicted an increased risk of long-term mortality and strongest for NT-proBNP and hs-cTnI. These results might help to identify subjects at risk and target preventive efforts early. |
format | Online Article Text |
id | pubmed-7710029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77100292020-12-03 Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis Rehm, Martin Büchele, Gisela Peter, Raphael Simon Brenner, Rolf Erwin Günther, Klaus-Peter Brenner, Hermann Koenig, Wolfgang Rothenbacher, Dietrich PLoS One Research Article Osteoarthritis (OA) is associated with adverse cardio-metabolic features. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponins T and I (hs-cTnT and hs-cTnI) are well-characterized cardiac markers and provide prognostic information. The objective was to assess the association of cardiac biomarker concentrations with long-term mortality in subjects with OA. In a cohort of 679 OA subjects, undergoing hip or knee replacement during 1995/1996, cardiac biomarkers were measured and subjects were followed over 20 years. During a median follow-up of 18.4 years, 332 (48.9%) subjects died. Median of hs-cTnT, hs-cTnI, and NT-proBNP at baseline was 3.2 ng/L, 3.9 ng/L, and 96.8 ng/L. The top quartile of NT-proBNP was associated with increased risk of mortality (Hazard Ratio (HR) 1.79, 95% confidence interval (CI) 1.17–2.73) after adjustment for covariates including troponins (hs-cTnT HR 1.30 (95% CI 0.90–1.89), hs-cTnI HR 1.32 (95% CI 0.87–2.00) for top category). When biomarker associations were evaluated as continuous variables, only NT-proBNP (HR per log-unit increment 1.34, 95% CI 1.16–1.54) and hs-cTnI (HR 1.38, 95% CI 1.11–1.72) showed robust results. Elevated cardiac biomarker concentrations predicted an increased risk of long-term mortality and strongest for NT-proBNP and hs-cTnI. These results might help to identify subjects at risk and target preventive efforts early. Public Library of Science 2020-12-02 /pmc/articles/PMC7710029/ /pubmed/33264342 http://dx.doi.org/10.1371/journal.pone.0242814 Text en © 2020 Rehm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rehm, Martin Büchele, Gisela Peter, Raphael Simon Brenner, Rolf Erwin Günther, Klaus-Peter Brenner, Hermann Koenig, Wolfgang Rothenbacher, Dietrich Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title | Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title_full | Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title_fullStr | Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title_full_unstemmed | Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title_short | Relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
title_sort | relationship between cardiac biomarker concentrations and long-term mortality in subjects with osteoarthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710029/ https://www.ncbi.nlm.nih.gov/pubmed/33264342 http://dx.doi.org/10.1371/journal.pone.0242814 |
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