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Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis
BACKGROUND: Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710089/ https://www.ncbi.nlm.nih.gov/pubmed/33264319 http://dx.doi.org/10.1371/journal.pone.0242523 |
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author | Li, Peixuan Qin, Xiaoyun Tao, Fangbiao Huang, Kun |
author_facet | Li, Peixuan Qin, Xiaoyun Tao, Fangbiao Huang, Kun |
author_sort | Li, Peixuan |
collection | PubMed |
description | BACKGROUND: Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes. METHODS: We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study protocol was registered in PROSPERO with protocol number CRD42020178687. RESULTS: A total of 10 studies, and 1096350 participants were included for systematic review. Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% CI 1.07–1.37). The use of sulfonamides in the first trimester of pregnancy and during the entire pregnancy might be associated with congenital malformations. CONCLUSIONS: Maternal exposure to sulfonamides may be associated with offspring’ s congenital malformations. Prescription of sulfonamides for pregnant women is suggested to be carefully censored. |
format | Online Article Text |
id | pubmed-7710089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77100892020-12-03 Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis Li, Peixuan Qin, Xiaoyun Tao, Fangbiao Huang, Kun PLoS One Research Article BACKGROUND: Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes. METHODS: We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study protocol was registered in PROSPERO with protocol number CRD42020178687. RESULTS: A total of 10 studies, and 1096350 participants were included for systematic review. Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% CI 1.07–1.37). The use of sulfonamides in the first trimester of pregnancy and during the entire pregnancy might be associated with congenital malformations. CONCLUSIONS: Maternal exposure to sulfonamides may be associated with offspring’ s congenital malformations. Prescription of sulfonamides for pregnant women is suggested to be carefully censored. Public Library of Science 2020-12-02 /pmc/articles/PMC7710089/ /pubmed/33264319 http://dx.doi.org/10.1371/journal.pone.0242523 Text en © 2020 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Peixuan Qin, Xiaoyun Tao, Fangbiao Huang, Kun Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title | Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title_full | Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title_fullStr | Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title_full_unstemmed | Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title_short | Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis |
title_sort | maternal exposure to sulfonamides and adverse pregnancy outcomes: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710089/ https://www.ncbi.nlm.nih.gov/pubmed/33264319 http://dx.doi.org/10.1371/journal.pone.0242523 |
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