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Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review

BACKGROUND: Perioperative intravenous lidocaine has been reported to have analgesic and opioid-sparing effects in many kinds of surgery. Several studies have evaluated its use in the settings of spine surgery. The aim of the study is to examine the effect of intravenous lidocaine in patients undergo...

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Autores principales: Bi, Yaodan, Ye, Yu, Ma, Jun, Tian, Zerong, Zhang, Xiuqian, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710210/
https://www.ncbi.nlm.nih.gov/pubmed/33235097
http://dx.doi.org/10.1097/MD.0000000000023332
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author Bi, Yaodan
Ye, Yu
Ma, Jun
Tian, Zerong
Zhang, Xiuqian
Liu, Bin
author_facet Bi, Yaodan
Ye, Yu
Ma, Jun
Tian, Zerong
Zhang, Xiuqian
Liu, Bin
author_sort Bi, Yaodan
collection PubMed
description BACKGROUND: Perioperative intravenous lidocaine has been reported to have analgesic and opioid-sparing effects in many kinds of surgery. Several studies have evaluated its use in the settings of spine surgery. The aim of the study is to examine the effect of intravenous lidocaine in patients undergoing spine surgery. METHODS: We performed a quantitative systematic review. Databases of PubMed, Medline, Embase database and Cochrane library were investigated for eligible literatures from their establishments to June, 2019. Articles of randomized controlled trials that compared intravenous lidocaine to a control group in patients undergoing spine surgery were included. The primary outcome was postoperative pain intensity. Secondary outcomes included postoperative opioid consumption and the length of hospital stay. RESULT: Four randomized controlled trials with 275 patients were included in the study. postoperative pain compared with control was reduced at 6 hours after surgery (WMD −0.50, 95%CI, −0.76 to −0.25, P < .001), at 24 hours after surgery (WMD −0.50, 95%CI, −0.70 to −0.29, P < .001) and at 48 hours after surgery (WMD −0.57, 95%CI, −0.96 to −0.17, P = .005). The effect of intravenous lidocaine on postoperative opioid consumption compared with control revealed a significant effect (WMD −15.36, 95%CI, −21.40 to −9.33 mg intravenous morphine equivalents, P < .001). CONCLUSION: This quantitative analysis of randomized controlled trials demonstrated that the perioperative intravenous lidocaine was effective for reducing postoperative opioid consumption and pain in patients undergoing spine surgery. The intravenous lidocaine should be considered as an effective adjunct to improve analgesic outcomes in patients undergoing spine surgery. However, the quantity of the studies was very low, more research is needed.
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spelling pubmed-77102102020-12-03 Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review Bi, Yaodan Ye, Yu Ma, Jun Tian, Zerong Zhang, Xiuqian Liu, Bin Medicine (Baltimore) 3300 BACKGROUND: Perioperative intravenous lidocaine has been reported to have analgesic and opioid-sparing effects in many kinds of surgery. Several studies have evaluated its use in the settings of spine surgery. The aim of the study is to examine the effect of intravenous lidocaine in patients undergoing spine surgery. METHODS: We performed a quantitative systematic review. Databases of PubMed, Medline, Embase database and Cochrane library were investigated for eligible literatures from their establishments to June, 2019. Articles of randomized controlled trials that compared intravenous lidocaine to a control group in patients undergoing spine surgery were included. The primary outcome was postoperative pain intensity. Secondary outcomes included postoperative opioid consumption and the length of hospital stay. RESULT: Four randomized controlled trials with 275 patients were included in the study. postoperative pain compared with control was reduced at 6 hours after surgery (WMD −0.50, 95%CI, −0.76 to −0.25, P < .001), at 24 hours after surgery (WMD −0.50, 95%CI, −0.70 to −0.29, P < .001) and at 48 hours after surgery (WMD −0.57, 95%CI, −0.96 to −0.17, P = .005). The effect of intravenous lidocaine on postoperative opioid consumption compared with control revealed a significant effect (WMD −15.36, 95%CI, −21.40 to −9.33 mg intravenous morphine equivalents, P < .001). CONCLUSION: This quantitative analysis of randomized controlled trials demonstrated that the perioperative intravenous lidocaine was effective for reducing postoperative opioid consumption and pain in patients undergoing spine surgery. The intravenous lidocaine should be considered as an effective adjunct to improve analgesic outcomes in patients undergoing spine surgery. However, the quantity of the studies was very low, more research is needed. Lippincott Williams & Wilkins 2020-11-25 /pmc/articles/PMC7710210/ /pubmed/33235097 http://dx.doi.org/10.1097/MD.0000000000023332 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3300
Bi, Yaodan
Ye, Yu
Ma, Jun
Tian, Zerong
Zhang, Xiuqian
Liu, Bin
Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title_full Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title_fullStr Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title_full_unstemmed Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title_short Effect of perioperative intravenous lidocaine for patients undergoing spine surgery: A meta-analysis and systematic review
title_sort effect of perioperative intravenous lidocaine for patients undergoing spine surgery: a meta-analysis and systematic review
topic 3300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710210/
https://www.ncbi.nlm.nih.gov/pubmed/33235097
http://dx.doi.org/10.1097/MD.0000000000023332
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