Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury

Evidence for reduced expression of cyclin G associated kinase (GAK) in glomeruli of patients with chronic kidney disease was observed in the Nephroseq human database, and GAK was found to be associated with the decline in kidney function. To examine the role of GAK, a protein that functions to uncoa...

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Detalles Bibliográficos
Autores principales: Tian, Xuefei, Inoue, Kazunori, Zhang, Yan, Wang, Ying, Sperati, C. John, Pedigo, Christopher E., Zhao, Tingting, Yan, Meihua, Groener, Marwin, Moledina, Dennis G., Ebenezer, Karen, Li, Wei, Zhang, Zhenhai, Liebermann, Dan A., Greene, Lois, Greer, Peter, Parikh, Chirag R., Ishibe, Shuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710277/
https://www.ncbi.nlm.nih.gov/pubmed/33208557
http://dx.doi.org/10.1172/jci.insight.142740

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