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Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), 2 incurable neurodegenerative disorders, share the same pathological hallmark named TDP43 (TAR DNA binding protein 43) proteinopathy. This event is characterized by a consistent cytoplasmic mislocalization and aggregat...

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Detalles Bibliográficos
Autores principales:	Pozzi, Silvia, Codron, Philippe, Soucy, Geneviève, Renaud, Laurence, Cordeau, Pierre Junior, Dutta, Kallol, Bareil, Christine, Julien, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710295/ https://www.ncbi.nlm.nih.gov/pubmed/33021970 http://dx.doi.org/10.1172/jci.insight.140420

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