PDX-derived organoids model in vivo drug response and secrete biomarkers

Patient-derived organoid models are proving to be a powerful platform for both basic and translational studies. Here we conduct a methodical analysis of pancreatic ductal adenocarcinoma (PDAC) tumor organoid drug response in paired patient-derived xenograft (PDX) and PDX-derived organoid (PXO) model...

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Detalles Bibliográficos
Autores principales: Huang, Ling, Bockorny, Bruno, Paul, Indranil, Akshinthala, Dipikaa, Frappart, Pierre-Oliver, Gandarilla, Omar, Bose, Arindam, Sanchez-Gonzalez, Veronica, Rouse, Emily E., Lehoux, Sylvain D., Pandell, Nicole, Lim, Christine M., Clohessy, John G., Grossman, Joseph, Gonzalez, Raul, Del Pino, Sofia Perea, Daaboul, George, Sawhney, Mandeep S., Freedman, Steven D., Kleger, Alexander, Cummings, Richard D., Emili, Andrew, Muthuswamy, Lakshmi B., Hidalgo, Manuel, Muthuswamy, Senthil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710298/
https://www.ncbi.nlm.nih.gov/pubmed/32990680
http://dx.doi.org/10.1172/jci.insight.135544

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