Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing

Plasma antimalarial Ab can mediate antiparasite immunity but has not previously been characterized at the molecular level. Here, we develop an innovative strategy to characterize humoral responses by integrating profiles of plasma immunoglobulins (IGs) or Abs with those expressed on B cells as part...

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Detalles Bibliográficos
Autores principales: Coelho, Camila H., Nadakal, Steven T., Gonzales Hurtado, Patricia, Morrison, Robert, Galson, Jacob D., Neal, Jillian, Wu, Yimin, King, C. Richter, Price, Virginia, Miura, Kazutoyo, Wong-Madden, Sharon, Alamou Doritchamou, Justin Yai, Narum, David L., MacDonald, Nicholas J., Snow-Smith, Maryonne, Vignali, Marissa, Taylor, Justin J., Lefranc, Marie-Paule, Trück, Johannes, Long, Carole A., Sagara, Issaka, Fried, Michal, Duffy, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710313/
https://www.ncbi.nlm.nih.gov/pubmed/33048842
http://dx.doi.org/10.1172/jci.insight.143471

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