Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness

Hypoglycemia is a frequent complication of diabetes, limiting therapy and increasing morbidity and mortality. With recurrent hypoglycemia, the counterregulatory response (CRR) to decreased blood glucose is blunted, resulting in hypoglycemia-associated autonomic failure (HAAF). The mechanisms leading...

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Detalles Bibliográficos
Autores principales: Bayne, Mitchell, Alvarsson, Alexandra, Devarakonda, Kavya, Li, Rosemary, Jimenez-Gonzalez, Maria, Garibay, Darline, Conner, Kaetlyn, Varghese, Merina, Serasinghe, Madhavika N., Chipuk, Jerry E., Hof, Patrick R., Stanley, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710320/
https://www.ncbi.nlm.nih.gov/pubmed/33148883
http://dx.doi.org/10.1172/jci.insight.133488

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