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2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease

The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment. The SARS-CoV-2 main protease (M(pro)) is an important enzyme for viral replication. Small molecules that inhibit this protease could lead to an effective COVID-19 tr...

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Detalles Bibliográficos
Autores principales: Forrestall, Katrina L., Burley, Darcy E., Cash, Meghan K., Pottie, Ian R., Darvesh, Sultan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710351/
https://www.ncbi.nlm.nih.gov/pubmed/33278462
http://dx.doi.org/10.1016/j.cbi.2020.109348