RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8(+) T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for re...

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Detalles Bibliográficos
Autores principales: Tullett, Kirsteen M, Tan, Peck Szee, Park, Hae-Young, Schittenhelm, Ralf B, Michael, Nicole, Li, Rong, Policheni, Antonia N, Gruber, Emily, Huang, Cheng, Fulcher, Alex J, Danne, Jillian C, Czabotar, Peter E, Wakim, Linda M, Mintern, Justine D, Ramm, Georg, Radford, Kristen J, Caminschi, Irina, O'Keeffe, Meredith, Villadangos, Jose A, Wright, Mark D, Blewitt, Marnie E, Heath, William R, Shortman, Ken, Purcell, Anthony W, Nicola, Nicos A, Zhang, Jian-Guo, Lahoud, Mireille H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710356/
https://www.ncbi.nlm.nih.gov/pubmed/33264090
http://dx.doi.org/10.7554/eLife.63452

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