Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige adipocyte identity. Here, we tested whether widespread changes in miRNA expression promoted by treatment with the small-molecule enoxacin cause browning and prevent obesity. Enoxacin mitigated diet-induced obesity in mic...

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Detalles Bibliográficos
Autores principales: Rocha, Andréa Livia, de Lima, Tanes Imamura, de Souza, Gerson Profeta, Corrêa, Renan Oliveira, Ferrucci, Danilo Lopes, Rodrigues, Bruno, Lopes-Ramos, Camila, Nilsson, Daniel, Knittel, Thiago Leite, Castro, Pollyana Ribeiro, Fernandes, Mariane Font, dos Santos Martins, Flaviano, Parmigiani, Raphael Bessa, Silveira, Leonardo Reis, Carvalho, Hernandes F., Auwerx, Johan, Vinolo, Marco Aurélio R., Boucher, Jeremie, Mori, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710362/
https://www.ncbi.nlm.nih.gov/pubmed/33268375
http://dx.doi.org/10.1126/sciadv.abc6250

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