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The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction
BACKGROUND: The aim of this study was to compare serum sclerostin concentrations in patients with thyroid dysfunction with euthyroid control subjects and to assess the relationship between sclerostin and markers of bone metabolism (osteocalcin and beta-cross-laps). METHODS: The study included 30 pat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society of Medical Biochemists of Serbia, Belgrade
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710371/ https://www.ncbi.nlm.nih.gov/pubmed/33312059 http://dx.doi.org/10.5937/jomb0-24943 |
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author | Mihaljević, Olgica Živančević-Simonović, Snežana Lučić-Tomić, Aleksandra Živković, Irena Minić, Rajna Mijatović-Teodorović, Ljiljana Jovanović, Zorica Anđelković, Marija Stanojević-Pirković, Marijana |
author_facet | Mihaljević, Olgica Živančević-Simonović, Snežana Lučić-Tomić, Aleksandra Živković, Irena Minić, Rajna Mijatović-Teodorović, Ljiljana Jovanović, Zorica Anđelković, Marija Stanojević-Pirković, Marijana |
author_sort | Mihaljević, Olgica |
collection | PubMed |
description | BACKGROUND: The aim of this study was to compare serum sclerostin concentrations in patients with thyroid dysfunction with euthyroid control subjects and to assess the relationship between sclerostin and markers of bone metabolism (osteocalcin and beta-cross-laps). METHODS: The study included 30 patients with thyroid dysfunction (hypothyroidism, hyperthyroidism and subclinical hyperthyroidism) and ten euthyroid controls. Free thyroxine (FT4) was measured by radioimmunoassay, while thyroid stimulating hormone (TSH) concentration was determined immunoradiometrically. We used an ELISA kit to determine the sclerostin level. The electrochemiluminescence method was applied for measuring the bone markers. RESULTS: Sclerostin levels were significantly lower in hypothyroid patients (p=0.009) and significantly elevated in hyperthyroid patients (p=0.008) compared to control values. Hyperthyroid patients also had higher sclerostin than patients with subclinical hyperthyroidism (p=0.013). Sclerostin concentrations were negatively correlated with TSH levels (r=-0.746, p<0.001), but positively with FT4 (r=0.696, p < 0.001). Moreover, sclerostin was positively associated with osteocalcin (r=0.605, p=0.005) and beta-cross-laps levels (r=0.573, p=0.008) in all thyroid patients. CONCLUSIONS: Serum sclerostin is significantly affected in subjects with thyroid dysfunction. Both sclerostin and thyroid status affect bone homeostasis, which is reflected through the significant correlations with osteocalcin and beta-cross-laps. |
format | Online Article Text |
id | pubmed-7710371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-77103712020-12-11 The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction Mihaljević, Olgica Živančević-Simonović, Snežana Lučić-Tomić, Aleksandra Živković, Irena Minić, Rajna Mijatović-Teodorović, Ljiljana Jovanović, Zorica Anđelković, Marija Stanojević-Pirković, Marijana J Med Biochem Original Paper BACKGROUND: The aim of this study was to compare serum sclerostin concentrations in patients with thyroid dysfunction with euthyroid control subjects and to assess the relationship between sclerostin and markers of bone metabolism (osteocalcin and beta-cross-laps). METHODS: The study included 30 patients with thyroid dysfunction (hypothyroidism, hyperthyroidism and subclinical hyperthyroidism) and ten euthyroid controls. Free thyroxine (FT4) was measured by radioimmunoassay, while thyroid stimulating hormone (TSH) concentration was determined immunoradiometrically. We used an ELISA kit to determine the sclerostin level. The electrochemiluminescence method was applied for measuring the bone markers. RESULTS: Sclerostin levels were significantly lower in hypothyroid patients (p=0.009) and significantly elevated in hyperthyroid patients (p=0.008) compared to control values. Hyperthyroid patients also had higher sclerostin than patients with subclinical hyperthyroidism (p=0.013). Sclerostin concentrations were negatively correlated with TSH levels (r=-0.746, p<0.001), but positively with FT4 (r=0.696, p < 0.001). Moreover, sclerostin was positively associated with osteocalcin (r=0.605, p=0.005) and beta-cross-laps levels (r=0.573, p=0.008) in all thyroid patients. CONCLUSIONS: Serum sclerostin is significantly affected in subjects with thyroid dysfunction. Both sclerostin and thyroid status affect bone homeostasis, which is reflected through the significant correlations with osteocalcin and beta-cross-laps. Society of Medical Biochemists of Serbia, Belgrade 2020-10-02 2020-10-02 /pmc/articles/PMC7710371/ /pubmed/33312059 http://dx.doi.org/10.5937/jomb0-24943 Text en 2020 Olgica Mihaljević, Snežana Živančević-Simonović, Aleksandra Lučić-Tomić, Irena Živković, Rajna Minić, Ljiljana Mijatović-Teodorović, Zorica Jovanović, Marija Anđelković, Marijana Stanojević-Pirković, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Original Paper Mihaljević, Olgica Živančević-Simonović, Snežana Lučić-Tomić, Aleksandra Živković, Irena Minić, Rajna Mijatović-Teodorović, Ljiljana Jovanović, Zorica Anđelković, Marija Stanojević-Pirković, Marijana The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title_full | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title_fullStr | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title_full_unstemmed | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title_short | The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
title_sort | association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710371/ https://www.ncbi.nlm.nih.gov/pubmed/33312059 http://dx.doi.org/10.5937/jomb0-24943 |
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