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Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710374/ https://www.ncbi.nlm.nih.gov/pubmed/33312063 http://dx.doi.org/10.5937/jomb0-24695 |
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author | Vekić, Jelena Ivanišević, Jasmina Zeljković, Aleksandra Spasojević-Kalimanovska, Vesna Bogavac-Stanojević, Nataša Mihajlović, Marija Janać, Jelena Vujčić, Sanja Miljković, Milica Zujović, Dejan Kotur-Stevuljević, Jelena |
author_facet | Vekić, Jelena Ivanišević, Jasmina Zeljković, Aleksandra Spasojević-Kalimanovska, Vesna Bogavac-Stanojević, Nataša Mihajlović, Marija Janać, Jelena Vujčić, Sanja Miljković, Milica Zujović, Dejan Kotur-Stevuljević, Jelena |
author_sort | Vekić, Jelena |
collection | PubMed |
description | BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated the effects of propolis and N-acetylcysteine supplementation (PropoMucil®) on lipid status, lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. METHODS: Twenty subjects with acute respiratory infection were included. PropoMucil® granules for oral solution (80 mg of dry propolis extract and 200 mg of N-acetylcysteine) were administered tree times per day for ten days. Serum lipid profile, paraoxonase 1 activity and low-density and high-density lipoprotein size and subclasses distribution were assessed at baseline and after supplementation. RESULTS: Following ten days of supplementation lipid status remained unchanged, but a significant increase of low-density lipoprotein particle size and proportion of high-density lipoprotein 3a particles were found (P<0.05). Moreover, supplementation with PropoMucil® significantly improved high-density lipoprotein particles distribution, particularly in those who smoke. There was a moderate increase of paraoxonase 1 activity, but without statistical significance. CONCLUSIONS: The presented study demonstrated that short-term supplementation with PropoMucil® has beneficial effects on low-density and high-density lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection particularly in those who smoke. |
format | Online Article Text |
id | pubmed-7710374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Society of Medical Biochemists of Serbia, Belgrade |
record_format | MEDLINE/PubMed |
spelling | pubmed-77103742020-12-11 Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection Vekić, Jelena Ivanišević, Jasmina Zeljković, Aleksandra Spasojević-Kalimanovska, Vesna Bogavac-Stanojević, Nataša Mihajlović, Marija Janać, Jelena Vujčić, Sanja Miljković, Milica Zujović, Dejan Kotur-Stevuljević, Jelena J Med Biochem Original Paper BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated the effects of propolis and N-acetylcysteine supplementation (PropoMucil®) on lipid status, lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. METHODS: Twenty subjects with acute respiratory infection were included. PropoMucil® granules for oral solution (80 mg of dry propolis extract and 200 mg of N-acetylcysteine) were administered tree times per day for ten days. Serum lipid profile, paraoxonase 1 activity and low-density and high-density lipoprotein size and subclasses distribution were assessed at baseline and after supplementation. RESULTS: Following ten days of supplementation lipid status remained unchanged, but a significant increase of low-density lipoprotein particle size and proportion of high-density lipoprotein 3a particles were found (P<0.05). Moreover, supplementation with PropoMucil® significantly improved high-density lipoprotein particles distribution, particularly in those who smoke. There was a moderate increase of paraoxonase 1 activity, but without statistical significance. CONCLUSIONS: The presented study demonstrated that short-term supplementation with PropoMucil® has beneficial effects on low-density and high-density lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection particularly in those who smoke. Society of Medical Biochemists of Serbia, Belgrade 2020-10-02 2020-10-02 /pmc/articles/PMC7710374/ /pubmed/33312063 http://dx.doi.org/10.5937/jomb0-24695 Text en 2020 Jelena Vekić, Jasmina Ivanišević, Aleksandra Zeljković, Vesna Spasojević-Kalimanovska, Nataša Bogavac-Stanojević, Marija Mihajlović, Jelena Janać, Sanja Vujčić, Milica Miljković, Dejan Zujović, Jelena Kotur-Stevuljević, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License. |
spellingShingle | Original Paper Vekić, Jelena Ivanišević, Jasmina Zeljković, Aleksandra Spasojević-Kalimanovska, Vesna Bogavac-Stanojević, Nataša Mihajlović, Marija Janać, Jelena Vujčić, Sanja Miljković, Milica Zujović, Dejan Kotur-Stevuljević, Jelena Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title | Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title_full | Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title_fullStr | Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title_full_unstemmed | Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title_short | Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
title_sort | effect of propolis and n-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710374/ https://www.ncbi.nlm.nih.gov/pubmed/33312063 http://dx.doi.org/10.5937/jomb0-24695 |
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