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Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection

BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated th...

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Autores principales: Vekić, Jelena, Ivanišević, Jasmina, Zeljković, Aleksandra, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Mihajlović, Marija, Janać, Jelena, Vujčić, Sanja, Miljković, Milica, Zujović, Dejan, Kotur-Stevuljević, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia, Belgrade 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710374/
https://www.ncbi.nlm.nih.gov/pubmed/33312063
http://dx.doi.org/10.5937/jomb0-24695
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author Vekić, Jelena
Ivanišević, Jasmina
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Mihajlović, Marija
Janać, Jelena
Vujčić, Sanja
Miljković, Milica
Zujović, Dejan
Kotur-Stevuljević, Jelena
author_facet Vekić, Jelena
Ivanišević, Jasmina
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Mihajlović, Marija
Janać, Jelena
Vujčić, Sanja
Miljković, Milica
Zujović, Dejan
Kotur-Stevuljević, Jelena
author_sort Vekić, Jelena
collection PubMed
description BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated the effects of propolis and N-acetylcysteine supplementation (PropoMucil®) on lipid status, lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. METHODS: Twenty subjects with acute respiratory infection were included. PropoMucil® granules for oral solution (80 mg of dry propolis extract and 200 mg of N-acetylcysteine) were administered tree times per day for ten days. Serum lipid profile, paraoxonase 1 activity and low-density and high-density lipoprotein size and subclasses distribution were assessed at baseline and after supplementation. RESULTS: Following ten days of supplementation lipid status remained unchanged, but a significant increase of low-density lipoprotein particle size and proportion of high-density lipoprotein 3a particles were found (P<0.05). Moreover, supplementation with PropoMucil® significantly improved high-density lipoprotein particles distribution, particularly in those who smoke. There was a moderate increase of paraoxonase 1 activity, but without statistical significance. CONCLUSIONS: The presented study demonstrated that short-term supplementation with PropoMucil® has beneficial effects on low-density and high-density lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection particularly in those who smoke.
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spelling pubmed-77103742020-12-11 Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection Vekić, Jelena Ivanišević, Jasmina Zeljković, Aleksandra Spasojević-Kalimanovska, Vesna Bogavac-Stanojević, Nataša Mihajlović, Marija Janać, Jelena Vujčić, Sanja Miljković, Milica Zujović, Dejan Kotur-Stevuljević, Jelena J Med Biochem Original Paper BACKGROUND: Propolis and N-acetylcysteine have positive impact on respiratory tract health. Also, it has been suggested that they have beneficial effects on serum lipid and oxidative stress status, but the available data are limited and mostly gained from animal models. In this study we evaluated the effects of propolis and N-acetylcysteine supplementation (PropoMucil®) on lipid status, lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection. METHODS: Twenty subjects with acute respiratory infection were included. PropoMucil® granules for oral solution (80 mg of dry propolis extract and 200 mg of N-acetylcysteine) were administered tree times per day for ten days. Serum lipid profile, paraoxonase 1 activity and low-density and high-density lipoprotein size and subclasses distribution were assessed at baseline and after supplementation. RESULTS: Following ten days of supplementation lipid status remained unchanged, but a significant increase of low-density lipoprotein particle size and proportion of high-density lipoprotein 3a particles were found (P<0.05). Moreover, supplementation with PropoMucil® significantly improved high-density lipoprotein particles distribution, particularly in those who smoke. There was a moderate increase of paraoxonase 1 activity, but without statistical significance. CONCLUSIONS: The presented study demonstrated that short-term supplementation with PropoMucil® has beneficial effects on low-density and high-density lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection particularly in those who smoke. Society of Medical Biochemists of Serbia, Belgrade 2020-10-02 2020-10-02 /pmc/articles/PMC7710374/ /pubmed/33312063 http://dx.doi.org/10.5937/jomb0-24695 Text en 2020 Jelena Vekić, Jasmina Ivanišević, Aleksandra Zeljković, Vesna Spasojević-Kalimanovska, Nataša Bogavac-Stanojević, Marija Mihajlović, Jelena Janać, Sanja Vujčić, Milica Miljković, Dejan Zujović, Jelena Kotur-Stevuljević, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License.
spellingShingle Original Paper
Vekić, Jelena
Ivanišević, Jasmina
Zeljković, Aleksandra
Spasojević-Kalimanovska, Vesna
Bogavac-Stanojević, Nataša
Mihajlović, Marija
Janać, Jelena
Vujčić, Sanja
Miljković, Milica
Zujović, Dejan
Kotur-Stevuljević, Jelena
Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title_full Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title_fullStr Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title_full_unstemmed Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title_short Effect of propolis and N-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
title_sort effect of propolis and n-acetylcysteine supplementation on lipoprotein subclasses distribution and paraoxonase 1 activity in subjects with acute respiratory infection
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710374/
https://www.ncbi.nlm.nih.gov/pubmed/33312063
http://dx.doi.org/10.5937/jomb0-24695
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