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Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin

BACKGROUND: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased AD...

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Autores principales: Avci, Emre, Karabulut, Alpaslan, Alp, Avci Gulcin, Baba, Burcu, Bilgi, Cumhur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia, Belgrade 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710377/
https://www.ncbi.nlm.nih.gov/pubmed/33312061
http://dx.doi.org/10.5937/jomb0-24683
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author Avci, Emre
Karabulut, Alpaslan
Alp, Avci Gulcin
Baba, Burcu
Bilgi, Cumhur
author_facet Avci, Emre
Karabulut, Alpaslan
Alp, Avci Gulcin
Baba, Burcu
Bilgi, Cumhur
author_sort Avci, Emre
collection PubMed
description BACKGROUND: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased ADMA associated with cardiovascular disease (CVD) risk has been reported in many states. Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-γ) is emphasized in recent findings. The current study aims to investigate ADMA and NP levels which may assume a role in guiding the early diagnosis of coronary artery disease in obesity. METHODS: This is an original research study in which ADMA and NP levels of 50 patients (25 male/25 female) diagnosed with obesity were compared with those of 30 healthy individuals (15 male/15 female) as control. The high-performance liquid chromatography (HPLC) method was used while determining parameters. RESULTS: ADMA and NP levels in obese individuals were found to be significantly higher than in those enrolled in the control. ADMA values were found to be higher in obese subjects (0.71±0.24 μmol/L) as compared with levels found in healthy subjects (0.58±0.16 μmol/L) (p<0.05). A significant increase of serum neopterin levels was found in obese subjects (8.8±3.5 μmol/L) as compared with controls (4.9±1.69 μmol/L) (p<0.05). Also, there was a strong positive correlation between NP and ADMA values in obese individuals (r=0.954). CONCLUSIONS: Our study revealed that obese subjects have higher ADMA and neopterin levels. These results demonstrated that both ADMA and NP levels may be potential risk factors for coronary heart disease in obesity.
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spelling pubmed-77103772020-12-11 Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin Avci, Emre Karabulut, Alpaslan Alp, Avci Gulcin Baba, Burcu Bilgi, Cumhur J Med Biochem Original Paper BACKGROUND: Obesity is responsible for high morbidity and mortality, both in developed and developing countries. It is associated with many chronic and metabolic diseases. Asymmetric dimethylarginine (ADMA) has been demonstrated to be a biomarker of endothelial dysfunction in humans and increased ADMA associated with cardiovascular disease (CVD) risk has been reported in many states. Neopterin (NP) produced by monocytes/macrophages in response to stimulation by interferon-gamma (IFN-γ) is emphasized in recent findings. The current study aims to investigate ADMA and NP levels which may assume a role in guiding the early diagnosis of coronary artery disease in obesity. METHODS: This is an original research study in which ADMA and NP levels of 50 patients (25 male/25 female) diagnosed with obesity were compared with those of 30 healthy individuals (15 male/15 female) as control. The high-performance liquid chromatography (HPLC) method was used while determining parameters. RESULTS: ADMA and NP levels in obese individuals were found to be significantly higher than in those enrolled in the control. ADMA values were found to be higher in obese subjects (0.71±0.24 μmol/L) as compared with levels found in healthy subjects (0.58±0.16 μmol/L) (p<0.05). A significant increase of serum neopterin levels was found in obese subjects (8.8±3.5 μmol/L) as compared with controls (4.9±1.69 μmol/L) (p<0.05). Also, there was a strong positive correlation between NP and ADMA values in obese individuals (r=0.954). CONCLUSIONS: Our study revealed that obese subjects have higher ADMA and neopterin levels. These results demonstrated that both ADMA and NP levels may be potential risk factors for coronary heart disease in obesity. Society of Medical Biochemists of Serbia, Belgrade 2020-10-02 2020-10-02 /pmc/articles/PMC7710377/ /pubmed/33312061 http://dx.doi.org/10.5937/jomb0-24683 Text en 2020 Emre Avci, Alpaslan Karabulut, Avci Gulcin Alp, Burcu Baba, Cumhur Bilgi, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License.
spellingShingle Original Paper
Avci, Emre
Karabulut, Alpaslan
Alp, Avci Gulcin
Baba, Burcu
Bilgi, Cumhur
Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title_full Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title_fullStr Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title_full_unstemmed Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title_short Crucial markers showing the risk of coronary artery disease in obesity: ADMA and neopterin
title_sort crucial markers showing the risk of coronary artery disease in obesity: adma and neopterin
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710377/
https://www.ncbi.nlm.nih.gov/pubmed/33312061
http://dx.doi.org/10.5937/jomb0-24683
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