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Hyperbaric oxygen for severe traumatic brain injury: a randomized trial

OBJECTIVE: The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. METHODS: A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they we...

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Autores principales: Zhong, Xianliang, Shan, Aijun, Xu, Jianzhong, Liang, Jian, Long, Ying, Du, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710397/
https://www.ncbi.nlm.nih.gov/pubmed/33050752
http://dx.doi.org/10.1177/0300060520939824
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author Zhong, Xianliang
Shan, Aijun
Xu, Jianzhong
Liang, Jian
Long, Ying
Du, Bo
author_facet Zhong, Xianliang
Shan, Aijun
Xu, Jianzhong
Liang, Jian
Long, Ying
Du, Bo
author_sort Zhong, Xianliang
collection PubMed
description OBJECTIVE: The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. METHODS: A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized. RESULTS: No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury. CONCLUSION: Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury.
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spelling pubmed-77103972020-12-08 Hyperbaric oxygen for severe traumatic brain injury: a randomized trial Zhong, Xianliang Shan, Aijun Xu, Jianzhong Liang, Jian Long, Ying Du, Bo J Int Med Res Retrospective Clinical Research Report OBJECTIVE: The present study aimed to explore the effects of hyperbaric oxygen therapy on the prognosis and neurological function of patients with severe traumatic brain injury. METHODS: A prospective study was carried out in 88 patients diagnosed with severe brain injury at our hospital and they were enrolled as research participants and randomly assigned to control and experimental groups (n = 44 per group) using a random number table method. Both groups underwent routine treatment. Patients in the experimental group were administered hyperbaric oxygen therapy approximately 1 week after admission when their vital signs had stabilized. RESULTS: No significant intergroup differences were observed in the Glasgow Coma Scale (GCS) and U.S. National Institutes of Health Stroke Scale (NIHSS) scores before treatment. However, after oxygen treatment, compared with the control group, the experimental group showed higher GCS and lower NIHSS scores. The GCS score at admission, tracheotomy status, and first hyperbaric oxygen therapy duration were independent prognostic factors in patients with severe traumatic brain injury. CONCLUSION: Hyperbaric oxygen therapy may promote recovery of neurological function and improve the cognitive function and prognosis of patients with severe traumatic brain injury. SAGE Publications 2020-10-13 /pmc/articles/PMC7710397/ /pubmed/33050752 http://dx.doi.org/10.1177/0300060520939824 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Zhong, Xianliang
Shan, Aijun
Xu, Jianzhong
Liang, Jian
Long, Ying
Du, Bo
Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title_full Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title_fullStr Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title_full_unstemmed Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title_short Hyperbaric oxygen for severe traumatic brain injury: a randomized trial
title_sort hyperbaric oxygen for severe traumatic brain injury: a randomized trial
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710397/
https://www.ncbi.nlm.nih.gov/pubmed/33050752
http://dx.doi.org/10.1177/0300060520939824
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