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Generation of a cold-adapted PRRSV with a nucleotide substitution in the ORF5 and numerous mutations in the hypervariable region of NSP2

A cold-adapted porcine reproductive and respiratory syndrome virus (CA-VR2332) was generated from the modified live virus strain VR2332. CA-VR2332 showed impaired growth when cultured at 37°C with numerous mutations ((S)731(F), (E)819(D), (G)975(E), and (D)1014(N)) in the hypervariable region of the...

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Detalles Bibliográficos
Autores principales: Do, Van Tan, Dao, Hoai Thu, Hahn, Tae-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710459/
https://www.ncbi.nlm.nih.gov/pubmed/33263232
http://dx.doi.org/10.4142/jvs.2020.21.e85