Cargando…

Generation of a cold-adapted PRRSV with a nucleotide substitution in the ORF5 and numerous mutations in the hypervariable region of NSP2

A cold-adapted porcine reproductive and respiratory syndrome virus (CA-VR2332) was generated from the modified live virus strain VR2332. CA-VR2332 showed impaired growth when cultured at 37°C with numerous mutations ((S)731(F), (E)819(D), (G)975(E), and (D)1014(N)) in the hypervariable region of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Do, Van Tan, Dao, Hoai Thu, Hahn, Tae-Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Veterinary Science 2020
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710459/ https://www.ncbi.nlm.nih.gov/pubmed/33263232 http://dx.doi.org/10.4142/jvs.2020.21.e85

Ejemplares similares

Involvement of PRRSV NSP3 and NSP5 in the autophagy process
por: Zhang, Wei, et al.
Publicado: (2019)

Molecular Characterization of the Nsp2 and ORF5s of PRRSV Strains in Sichuan China during 2012–2020
por: Zhao, Jun, et al.
Publicado: (2022)

Molecular Characterization of the Nsp2 and ORF5 (ORF5a) Genes of PRRSV Strains in Nine Provinces of China During 2016–2018
por: Yin, Baishuang, et al.
Publicado: (2021)

Murine hepatitis virus nsp4 N258T mutants are not temperature-sensitive
por: Beachboard, Dia C., et al.
Publicado: (2013)

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021
por: Mazur-Panasiuk, Natalia, et al.
Publicado: (2021)

Characterization of Two Immunodominant Antigenic Peptides in NSP2 of PRRSV-2 and Generation of a Marker PRRSV Strain Based on the Peptides
por: Li, Dong-Yan, et al.
Publicado: (2022)

Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction
por: Zhou, Shaochuan, et al.
Publicado: (2019)

NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
por: Han, Tianyu, et al.
Publicado: (2022)

Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells
por: Shi, Xibao, et al.
Publicado: (2016)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

NSP2 gene variation of the North American genotype of the Thai PRRSV in central Thailand
por: Kedkovid, Roongtham, et al.
Publicado: (2010)

Epitope mapping and characterization of a novel Nsp10-specific monoclonal antibody that differentiates genotype 2 PRRSV from genotype 1 PRRSV
por: Zhang, Zhibang, et al.
Publicado: (2017)

Conserved motifs in the hypervariable domain of chikungunya virus nsP3 required for transmission by Aedes aegypti mosquitoes
por: Göertz, Giel P., et al.
Publicado: (2018)

Construction and immunization with double mutant ΔapxIBD Δpnp forms of Actinobacillus pleuropneumoniae serotypes 1 and 5
por: Dao, Hoai Thu, et al.
Publicado: (2020)

Enhancement of Apx Toxin Production in Actinobacillus pleuropneumoniae Serotypes 1, 2, and 5 by Optimizing Culture Conditions
por: Dao, Hoai Thu, et al.
Publicado: (2020)

Genetic variation analyses of nsp2 gene of PRRSV in Ningxia Hui Autonomous Region of China
por: Tian, Hong, et al.
Publicado: (2009)

A recombination between two Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV‐1) vaccine strains has caused severe outbreaks in Danish pigs
por: Kvisgaard, Lise Kirstine, et al.
Publicado: (2020)

MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication
por: Deming, Damon J., et al.
Publicado: (2006)

Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronaviruses
por: Akaishi, Tetsuya, et al.
Publicado: (2022)

Structural insights into type I and type II of nsp4 porcine reproductive and respiratory syndrome virus (nsp4 PRRSV) by molecular dynamics simulations
por: Aeksiri, Niran, et al.
Publicado: (2017)

Full-length ORF2 sequence-based genetic and phylogenetic characterization of Korean feline caliciviruses
por: Kim, Sung Jae, et al.
Publicado: (2021)

Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein
por: Dawood, Ali Adel
Publicado: (2023)

Determination of binding affinity of tunicamycin with SARS-CoV-2 proteins: Proteinase, protease, nsp2, nsp9, ORF3a, ORF7a, ORF8, ORF9b, envelope and RBD of spike glycoprotein
por: Dawood, Ali Adel
Publicado: (2023)

The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis
por: Wang, Tong-Yun, et al.
Publicado: (2019)

Genetic Variability and Recombination of the NSP2 Gene of PRRSV-2 Strains in China from 1996 to 2021
por: Zhang, Hang, et al.
Publicado: (2023)

Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV): implication for the existence of two genotypes of PRRSV in the U.S.A. and Europe
por: Meng, X. -J., et al.
Publicado: (1995)

WGS- versus ORF5-Based Typing of PRRSV: A Belgian Case Study
por: Vandenbussche, Frank, et al.
Publicado: (2021)

Aspartic acid at residue 185 modulates the capacity of HP-PRRSV nsp4 to antagonize IFN-I expression
por: Wei, Ze-yu, et al.
Publicado: (2020)

Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of Escherichia coli as a mucosal vaccine
por: Do, Van Tan, et al.
Publicado: (2020)

Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain
por: Neyret, Aymeric, et al.
Publicado: (2022)

Mir-331-3p Inhibits PRRSV-2 Replication and Lung Injury by Targeting PRRSV-2 ORF1b and Porcine TNF-α
por: You, Xiangbin, et al.
Publicado: (2020)

Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses
por: Li, Y., et al.
Publicado: (2018)

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
por: Cao, Shengliang, et al.
Publicado: (2020)

Antigenic and Biological Characterization of ORF2–6 Variants at Early Times Following PRRSV Infection
por: Evans, Alyssa B., et al.
Publicado: (2017)

Small interfering RNA targeting nonstructural protein1 α (nsp1α) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells
por: Shi, Xibao, et al.
Publicado: (2015)

Effect of Object Orientation Angle on T2* Image and Reconstructed Magnetic Susceptibility: Numerical Simulations
por: Chen, Zikuan, et al.
Publicado: (2013)

Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies
por: Pathak, Rajesh Kumar, et al.
Publicado: (2022)

Polymorphic genetic characterization of the ORF7 gene of porcine reproductive and respiratory syndrome virus (PRRSV) in China
por: Hao, Xiaofang, et al.
Publicado: (2011)

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus
por: Mutso, Margit, et al.
Publicado: (2018)

Genome-wide single-nucleotide polymorphism data and mitochondrial hypervariable region 1 nucleotide sequence reveal the origin of the Akhal-Teke horse
por: Kang, Zhoucairang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vkaani3hnddi8b29ppflurfc6b