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Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer?
The MucR/Ros family protein is conserved in alpha-proteobacteria and characterized by its zinc-finger motif that has been proposed as the ancestral domain from which the eukaryotic C2H2 zinc-finger structure evolved. In the past decades, accumulated evidences have revealed MucR as a pleiotropic tran...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710501/ https://www.ncbi.nlm.nih.gov/pubmed/33304460 http://dx.doi.org/10.1016/j.csbj.2020.11.028 |
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author | Jiao, Jian Tian, Chang-Fu |
author_facet | Jiao, Jian Tian, Chang-Fu |
author_sort | Jiao, Jian |
collection | PubMed |
description | The MucR/Ros family protein is conserved in alpha-proteobacteria and characterized by its zinc-finger motif that has been proposed as the ancestral domain from which the eukaryotic C2H2 zinc-finger structure evolved. In the past decades, accumulated evidences have revealed MucR as a pleiotropic transcriptional regulator that integrating multiple functions such as virulence, symbiosis, cell cycle and various physiological processes. Scattered reports indicate that MucR mainly acts as a repressor, through oligomerization and binding to multiple sites of AT-rich target promoters. The N-terminal region and zinc-finger bearing C-terminal region of MucR mediate oligomerization and DNA-binding, respectively. These features are convergent to those of xenogeneic silencers such as H-NS, MvaT, Lsr2 and Rok, which are mainly found in other lineages. Phylogenetic analysis of MucR homologs suggests an ancestral origin of MucR in alpha- and delta-proteobacteria. Multiple independent duplication and lateral gene transfer events contribute to the diversity and phyletic distribution of MucR. Finally, we posed questions which remain unexplored regarding the putative roles of MucR as a xenogeneic silencer and a general manager in balancing adaptation and regulatory integration in the pangenome context. |
format | Online Article Text |
id | pubmed-7710501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-77105012020-12-09 Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? Jiao, Jian Tian, Chang-Fu Comput Struct Biotechnol J Review Article The MucR/Ros family protein is conserved in alpha-proteobacteria and characterized by its zinc-finger motif that has been proposed as the ancestral domain from which the eukaryotic C2H2 zinc-finger structure evolved. In the past decades, accumulated evidences have revealed MucR as a pleiotropic transcriptional regulator that integrating multiple functions such as virulence, symbiosis, cell cycle and various physiological processes. Scattered reports indicate that MucR mainly acts as a repressor, through oligomerization and binding to multiple sites of AT-rich target promoters. The N-terminal region and zinc-finger bearing C-terminal region of MucR mediate oligomerization and DNA-binding, respectively. These features are convergent to those of xenogeneic silencers such as H-NS, MvaT, Lsr2 and Rok, which are mainly found in other lineages. Phylogenetic analysis of MucR homologs suggests an ancestral origin of MucR in alpha- and delta-proteobacteria. Multiple independent duplication and lateral gene transfer events contribute to the diversity and phyletic distribution of MucR. Finally, we posed questions which remain unexplored regarding the putative roles of MucR as a xenogeneic silencer and a general manager in balancing adaptation and regulatory integration in the pangenome context. Research Network of Computational and Structural Biotechnology 2020-11-19 /pmc/articles/PMC7710501/ /pubmed/33304460 http://dx.doi.org/10.1016/j.csbj.2020.11.028 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Jiao, Jian Tian, Chang-Fu Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title | Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title_full | Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title_fullStr | Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title_full_unstemmed | Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title_short | Ancestral zinc-finger bearing protein MucR in alpha-proteobacteria: A novel xenogeneic silencer? |
title_sort | ancestral zinc-finger bearing protein mucr in alpha-proteobacteria: a novel xenogeneic silencer? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710501/ https://www.ncbi.nlm.nih.gov/pubmed/33304460 http://dx.doi.org/10.1016/j.csbj.2020.11.028 |
work_keys_str_mv | AT jiaojian ancestralzincfingerbearingproteinmucrinalphaproteobacteriaanovelxenogeneicsilencer AT tianchangfu ancestralzincfingerbearingproteinmucrinalphaproteobacteriaanovelxenogeneicsilencer |