Functionally-informed fine-mapping and polygenic localization of complex trait heritability

Fine-mapping aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-mapping accuracy by leveraging functional annotations across the entire genome—not just genome-wide significant loci—to specify prior probabilities for fin...

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Detalles Bibliográficos
Autores principales: Weissbrod, Omer, Hormozdiari, Farhad, Benner, Christian, Cui, Ran, Ulirsch, Jacob, Gazal, Steven, Schoech, Armin P., van de Geijn, Bryce, Reshef, Yakir, Márquez-Luna, Carla, O’Connor, Luke, Pirinen, Matti, Finucane, Hilary K., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710571/
https://www.ncbi.nlm.nih.gov/pubmed/33199916
http://dx.doi.org/10.1038/s41588-020-00735-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710571/
https://www.ncbi.nlm.nih.gov/pubmed/33199916
http://dx.doi.org/10.1038/s41588-020-00735-5

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