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Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children

BACKGROUND: Psychosocial stress in early childhood is associated with adult obesity and cardiometabolic disease. The association of psychosocial stress with the metabolome in childhood is unknown. METHOD: Low-income children (n=28, mean age 1.8 years) recruited from the community, participated. Psyc...

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Autores principales: LaBarre, Jennifer L., Miller, Alison L., Bauer, Katherine W., Burant, Charles F., Lumeng, Julie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710594/
https://www.ncbi.nlm.nih.gov/pubmed/32492693
http://dx.doi.org/10.1038/s41390-020-0989-0
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author LaBarre, Jennifer L.
Miller, Alison L.
Bauer, Katherine W.
Burant, Charles F.
Lumeng, Julie C.
author_facet LaBarre, Jennifer L.
Miller, Alison L.
Bauer, Katherine W.
Burant, Charles F.
Lumeng, Julie C.
author_sort LaBarre, Jennifer L.
collection PubMed
description BACKGROUND: Psychosocial stress in early childhood is associated with adult obesity and cardiometabolic disease. The association of psychosocial stress with the metabolome in childhood is unknown. METHOD: Low-income children (n=28, mean age 1.8 years) recruited from the community, participated. Psychosocial stress was measured by diurnal salivary cortisol (cortisol intercept and slope) and by mother-reported chaos in the home using the Confusion, Hubbub, and Order Scale (CHAOS). At mean age 6.1 years, anthropometry was collected and fasting metabolites measured using an untargeted metabolomics and shotgun lipidomics platform. RESULTS: Cortisol slope was inversely associated with fatty acid (FA) 20:3, FA 20:4 and polyunsaturated fatty acids (PUFA) metabolites. A higher CHAOS score was associated with lower very long-chain PUFA metabolites and a trend towards lower long-chain PUFA containing triglycerides. CONCLUSION: Psychosocial stress in early childhood, measured with both biological markers and parent report, was associated with lower PUFAs later in childhood. Future work should examine potential mechanisms of association, including dietary intake or direct effects on polyunsaturated fatty acid levels or metabolism.
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spelling pubmed-77105942021-05-15 Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children LaBarre, Jennifer L. Miller, Alison L. Bauer, Katherine W. Burant, Charles F. Lumeng, Julie C. Pediatr Res Article BACKGROUND: Psychosocial stress in early childhood is associated with adult obesity and cardiometabolic disease. The association of psychosocial stress with the metabolome in childhood is unknown. METHOD: Low-income children (n=28, mean age 1.8 years) recruited from the community, participated. Psychosocial stress was measured by diurnal salivary cortisol (cortisol intercept and slope) and by mother-reported chaos in the home using the Confusion, Hubbub, and Order Scale (CHAOS). At mean age 6.1 years, anthropometry was collected and fasting metabolites measured using an untargeted metabolomics and shotgun lipidomics platform. RESULTS: Cortisol slope was inversely associated with fatty acid (FA) 20:3, FA 20:4 and polyunsaturated fatty acids (PUFA) metabolites. A higher CHAOS score was associated with lower very long-chain PUFA metabolites and a trend towards lower long-chain PUFA containing triglycerides. CONCLUSION: Psychosocial stress in early childhood, measured with both biological markers and parent report, was associated with lower PUFAs later in childhood. Future work should examine potential mechanisms of association, including dietary intake or direct effects on polyunsaturated fatty acid levels or metabolism. 2020-06-03 2021-04 /pmc/articles/PMC7710594/ /pubmed/32492693 http://dx.doi.org/10.1038/s41390-020-0989-0 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
LaBarre, Jennifer L.
Miller, Alison L.
Bauer, Katherine W.
Burant, Charles F.
Lumeng, Julie C.
Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title_full Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title_fullStr Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title_full_unstemmed Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title_short Early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
title_sort early life stress exposure associated with reduced polyunsaturated-containing lipids in low-income children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710594/
https://www.ncbi.nlm.nih.gov/pubmed/32492693
http://dx.doi.org/10.1038/s41390-020-0989-0
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