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Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by gradual degeneration and elimination of motor neurons (MNs) in the motor cortex, brainstem, and spinal cord. Some familial forms of ALS are caused by genetic mutations in superoxide dismutase 1 (SOD1) but the...

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Detalles Bibliográficos
Autores principales:	Kim, Byung Woo, Ryu, Jiwon, Jeong, Ye Eun, Kim, Juhyun, Martin, Lee J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710664/ https://www.ncbi.nlm.nih.gov/pubmed/33328898 http://dx.doi.org/10.3389/fncel.2020.604171

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