Building genomes to understand biology

Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes...

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Detalles Bibliográficos
Autores principales: Coradini, Alessandro L. V., Hull, Cara B., Ehrenreich, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710724/
https://www.ncbi.nlm.nih.gov/pubmed/33268788
http://dx.doi.org/10.1038/s41467-020-19753-2
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author Coradini, Alessandro L. V.
Hull, Cara B.
Ehrenreich, Ian M.
author_facet Coradini, Alessandro L. V.
Hull, Cara B.
Ehrenreich, Ian M.
author_sort Coradini, Alessandro L. V.
collection PubMed
description Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic manipulation. By facilitating complex modifications to chromosome content and structure, synthetic genomics opens new opportunities for studying biology through genetic manipulation. Here, we discuss different classes of genetic manipulation that are enabled by synthetic genomics, as well as biological problems they each can help solve.
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spelling pubmed-77107242020-12-03 Building genomes to understand biology Coradini, Alessandro L. V. Hull, Cara B. Ehrenreich, Ian M. Nat Commun Perspective Genetic manipulation is one of the central strategies that biologists use to investigate the molecular underpinnings of life and its diversity. Thus, advances in genetic manipulation usually lead to a deeper understanding of biological systems. During the last decade, the construction of chromosomes, known as synthetic genomics, has emerged as a novel approach to genetic manipulation. By facilitating complex modifications to chromosome content and structure, synthetic genomics opens new opportunities for studying biology through genetic manipulation. Here, we discuss different classes of genetic manipulation that are enabled by synthetic genomics, as well as biological problems they each can help solve. Nature Publishing Group UK 2020-12-02 /pmc/articles/PMC7710724/ /pubmed/33268788 http://dx.doi.org/10.1038/s41467-020-19753-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Coradini, Alessandro L. V.
Hull, Cara B.
Ehrenreich, Ian M.
Building genomes to understand biology
title Building genomes to understand biology
title_full Building genomes to understand biology
title_fullStr Building genomes to understand biology
title_full_unstemmed Building genomes to understand biology
title_short Building genomes to understand biology
title_sort building genomes to understand biology
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710724/
https://www.ncbi.nlm.nih.gov/pubmed/33268788
http://dx.doi.org/10.1038/s41467-020-19753-2
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