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CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function

While effective in specific settings, adoptive chimeric antigen receptor (CAR) T cell therapy for cancer requires further improvement and optimization. Our previous results show that CD40L-overexpressing CAR T cells mobilize endogenous immune effectors, resulting in improved antitumor immunity. Howe...

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Detalles Bibliográficos
Autores principales:	Kuhn, Nicholas F., Lopez, Andrea V., Li, Xinghuo, Cai, Winson, Daniyan, Anthony F., Brentjens, Renier J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710757/ https://www.ncbi.nlm.nih.gov/pubmed/33268774 http://dx.doi.org/10.1038/s41467-020-19833-3

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