Cargando…

Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction

BACKGROUND: The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health. This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of...

Descripción completa

Detalles Bibliográficos
Autores principales: Benkirane, Hasnae, Heikel, Jaafar, Laamiri, Fatima Zahra, Bouziani, Amina, Lahmam, Houria, Al-Jawaldeh, Ayoub, El Haloui, Noureddine, Ennibi, Khalid, Akhtar-Khan, Naim, El Fahime, El Mostafa, Obtel, Majdouline, Barkat, Amina, Aguenaou, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710934/
https://www.ncbi.nlm.nih.gov/pubmed/33329044
http://dx.doi.org/10.3389/fphys.2020.595005
_version_ 1783618038031974400
author Benkirane, Hasnae
Heikel, Jaafar
Laamiri, Fatima Zahra
Bouziani, Amina
Lahmam, Houria
Al-Jawaldeh, Ayoub
El Haloui, Noureddine
Ennibi, Khalid
Akhtar-Khan, Naim
El Fahime, El Mostafa
Obtel, Majdouline
Barkat, Amina
Aguenaou, Hassan
author_facet Benkirane, Hasnae
Heikel, Jaafar
Laamiri, Fatima Zahra
Bouziani, Amina
Lahmam, Houria
Al-Jawaldeh, Ayoub
El Haloui, Noureddine
Ennibi, Khalid
Akhtar-Khan, Naim
El Fahime, El Mostafa
Obtel, Majdouline
Barkat, Amina
Aguenaou, Hassan
author_sort Benkirane, Hasnae
collection PubMed
description BACKGROUND: The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health. This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of infected patients and thousands of deaths around the world. In Morocco, despite the efforts made by the authorities, the SARS-CoV-2 continues to spread and constitutes a burden of morbidity and mortality. The objective of this study is to describe clinical characteristics of COVID-19 Moroccan patients and to establish the relationship between specific clinical symptoms, namely ageusia and/or anosmia, with these characteristics. METHODS: We performed a descriptive, non-interventional cross-sectional study analyzing data from 108 patients admitted to the VINCI clinic, Casablanca (Morocco). The database includes 39 parameters including epidemiological characteristics, anthropometric measurements and biological analyzes. RESULTS: The average of age of the patients was 43.80 ± 15.75 years with a sex ratio of 1:1. The mean body mass index of the patients was 25.54 ± 4.63 Kg/m(2). The majority of patients had, at least, one comorbidity and among 75% symptomatic patients, about 50% had, at least, three symptoms namely, fever (40.7%), cough (39.8%), myalgia (28.7%), and anosmia and/or ageusia (20.4%). From biological analyzes, we noticed lymphopenia and an elevated protein C reactive and lactate dehydrogenases levels in 24.1, 36.1, and 35.2% of patients, respectively. A disturbance in liver function markers was observed in 15.7% of cases. For the other hemostasis parameters, high levels of prothrombin and platelets were reported in 14.6 and 14.8% of patients, respectively. Comparisons related to the presence of anosmia and/or ageusia did not show any difference for demographic and anthropometric characteristics, while a possibility of a significant difference was revealed for certain biological parameters, particularly the levels of lymphocytes, D-dimer and troponin. CONCLUSION: This study provides significant findings that will be used not only to supplement previous studies carried out in Morocco in order to resume the epidemiological situation in comparison with other countries, but also to improve the quality of the diagnosis of COVID-19 patients by identifying all the symptoms of the disease and better understanding its clinical outcomes.
format Online
Article
Text
id pubmed-7710934
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77109342020-12-15 Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction Benkirane, Hasnae Heikel, Jaafar Laamiri, Fatima Zahra Bouziani, Amina Lahmam, Houria Al-Jawaldeh, Ayoub El Haloui, Noureddine Ennibi, Khalid Akhtar-Khan, Naim El Fahime, El Mostafa Obtel, Majdouline Barkat, Amina Aguenaou, Hassan Front Physiol Physiology BACKGROUND: The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health. This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of infected patients and thousands of deaths around the world. In Morocco, despite the efforts made by the authorities, the SARS-CoV-2 continues to spread and constitutes a burden of morbidity and mortality. The objective of this study is to describe clinical characteristics of COVID-19 Moroccan patients and to establish the relationship between specific clinical symptoms, namely ageusia and/or anosmia, with these characteristics. METHODS: We performed a descriptive, non-interventional cross-sectional study analyzing data from 108 patients admitted to the VINCI clinic, Casablanca (Morocco). The database includes 39 parameters including epidemiological characteristics, anthropometric measurements and biological analyzes. RESULTS: The average of age of the patients was 43.80 ± 15.75 years with a sex ratio of 1:1. The mean body mass index of the patients was 25.54 ± 4.63 Kg/m(2). The majority of patients had, at least, one comorbidity and among 75% symptomatic patients, about 50% had, at least, three symptoms namely, fever (40.7%), cough (39.8%), myalgia (28.7%), and anosmia and/or ageusia (20.4%). From biological analyzes, we noticed lymphopenia and an elevated protein C reactive and lactate dehydrogenases levels in 24.1, 36.1, and 35.2% of patients, respectively. A disturbance in liver function markers was observed in 15.7% of cases. For the other hemostasis parameters, high levels of prothrombin and platelets were reported in 14.6 and 14.8% of patients, respectively. Comparisons related to the presence of anosmia and/or ageusia did not show any difference for demographic and anthropometric characteristics, while a possibility of a significant difference was revealed for certain biological parameters, particularly the levels of lymphocytes, D-dimer and troponin. CONCLUSION: This study provides significant findings that will be used not only to supplement previous studies carried out in Morocco in order to resume the epidemiological situation in comparison with other countries, but also to improve the quality of the diagnosis of COVID-19 patients by identifying all the symptoms of the disease and better understanding its clinical outcomes. Frontiers Media S.A. 2020-11-19 /pmc/articles/PMC7710934/ /pubmed/33329044 http://dx.doi.org/10.3389/fphys.2020.595005 Text en Copyright © 2020 Benkirane, Heikel, Laamiri, Bouziani, Lahmam, Al-Jawaldeh, El Haloui, Ennibi, Akhtar-Khan, El Fahime, Obtel, Barkat and Aguenaou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Benkirane, Hasnae
Heikel, Jaafar
Laamiri, Fatima Zahra
Bouziani, Amina
Lahmam, Houria
Al-Jawaldeh, Ayoub
El Haloui, Noureddine
Ennibi, Khalid
Akhtar-Khan, Naim
El Fahime, El Mostafa
Obtel, Majdouline
Barkat, Amina
Aguenaou, Hassan
Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title_full Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title_fullStr Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title_full_unstemmed Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title_short Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction
title_sort study of clinical and biological characteristics of moroccan covid-19 patients with and without olfactory and/or gustatory dysfunction
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710934/
https://www.ncbi.nlm.nih.gov/pubmed/33329044
http://dx.doi.org/10.3389/fphys.2020.595005
work_keys_str_mv AT benkiranehasnae studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT heikeljaafar studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT laamirifatimazahra studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT bouzianiamina studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT lahmamhouria studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT aljawaldehayoub studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT elhalouinoureddine studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT ennibikhalid studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT akhtarkhannaim studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT elfahimeelmostafa studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT obtelmajdouline studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT barkatamina studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction
AT aguenaouhassan studyofclinicalandbiologicalcharacteristicsofmoroccancovid19patientswithandwithoutolfactoryandorgustatorydysfunction