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Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo

Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input...

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Autores principales: Baaske, Magdalena K., Kormann, Eszter, Holt, Abbey B., Gulberti, Alessandro, McNamara, Colin G., Pötter-Nerger, Monika, Westphal, Manfred, Engel, Andreas K., Hamel, Wolfgang, Brown, Peter, Moll, Christian K.E., Sharott, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710979/
https://www.ncbi.nlm.nih.gov/pubmed/32991998
http://dx.doi.org/10.1016/j.nbd.2020.105119
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author Baaske, Magdalena K.
Kormann, Eszter
Holt, Abbey B.
Gulberti, Alessandro
McNamara, Colin G.
Pötter-Nerger, Monika
Westphal, Manfred
Engel, Andreas K.
Hamel, Wolfgang
Brown, Peter
Moll, Christian K.E.
Sharott, Andrew
author_facet Baaske, Magdalena K.
Kormann, Eszter
Holt, Abbey B.
Gulberti, Alessandro
McNamara, Colin G.
Pötter-Nerger, Monika
Westphal, Manfred
Engel, Andreas K.
Hamel, Wolfgang
Brown, Peter
Moll, Christian K.E.
Sharott, Andrew
author_sort Baaske, Magdalena K.
collection PubMed
description Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at other frequencies, and how such a preference would arise following dopamine depletion. To address this question, we combined analysis of cortical and STN recordings from awake human PD patients undergoing deep brain stimulation surgery with recordings of identified STN neurons in anaesthetised rats. In these patients, we demonstrate that a subset of putative STN neurons is strongly and selectively sensitive to magnitude fluctuations of cortical beta oscillations over time, linearly increasing their phase-locking strength with respect to the full range of instantaneous amplitude in the beta-frequency range. In rats, we probed the frequency response of STN neurons in the cortico-basal-ganglia-network more precisely, by recording spikes evoked by short bursts of cortical stimulation with variable frequency (4-40 Hz) and constant amplitude. In both healthy and dopamine-depleted rats, only beta-frequency stimulation led to a progressive reduction in the variability of spike timing through the stimulation train. This suggests, that the interval of beta-frequency input provides an optimal window for eliciting the next spike with high fidelity. We hypothesize, that abnormal activation of the indirect pathway, via dopamine depletion and/or cortical stimulation, could trigger an underlying sensitivity of the STN microcircuit to beta-frequency input.
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spelling pubmed-77109792020-12-09 Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo Baaske, Magdalena K. Kormann, Eszter Holt, Abbey B. Gulberti, Alessandro McNamara, Colin G. Pötter-Nerger, Monika Westphal, Manfred Engel, Andreas K. Hamel, Wolfgang Brown, Peter Moll, Christian K.E. Sharott, Andrew Neurobiol Dis Article Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at other frequencies, and how such a preference would arise following dopamine depletion. To address this question, we combined analysis of cortical and STN recordings from awake human PD patients undergoing deep brain stimulation surgery with recordings of identified STN neurons in anaesthetised rats. In these patients, we demonstrate that a subset of putative STN neurons is strongly and selectively sensitive to magnitude fluctuations of cortical beta oscillations over time, linearly increasing their phase-locking strength with respect to the full range of instantaneous amplitude in the beta-frequency range. In rats, we probed the frequency response of STN neurons in the cortico-basal-ganglia-network more precisely, by recording spikes evoked by short bursts of cortical stimulation with variable frequency (4-40 Hz) and constant amplitude. In both healthy and dopamine-depleted rats, only beta-frequency stimulation led to a progressive reduction in the variability of spike timing through the stimulation train. This suggests, that the interval of beta-frequency input provides an optimal window for eliciting the next spike with high fidelity. We hypothesize, that abnormal activation of the indirect pathway, via dopamine depletion and/or cortical stimulation, could trigger an underlying sensitivity of the STN microcircuit to beta-frequency input. Academic Press 2020-12 /pmc/articles/PMC7710979/ /pubmed/32991998 http://dx.doi.org/10.1016/j.nbd.2020.105119 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baaske, Magdalena K.
Kormann, Eszter
Holt, Abbey B.
Gulberti, Alessandro
McNamara, Colin G.
Pötter-Nerger, Monika
Westphal, Manfred
Engel, Andreas K.
Hamel, Wolfgang
Brown, Peter
Moll, Christian K.E.
Sharott, Andrew
Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title_full Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title_fullStr Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title_full_unstemmed Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title_short Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
title_sort parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710979/
https://www.ncbi.nlm.nih.gov/pubmed/32991998
http://dx.doi.org/10.1016/j.nbd.2020.105119
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