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Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells

Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more D...

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Autores principales: Lagunas-Rangel, Francisco Alejandro, Bermúdez-Cruz, Rosa María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710985/
https://www.ncbi.nlm.nih.gov/pubmed/33330091
http://dx.doi.org/10.3389/fonc.2020.598174
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author Lagunas-Rangel, Francisco Alejandro
Bermúdez-Cruz, Rosa María
author_facet Lagunas-Rangel, Francisco Alejandro
Bermúdez-Cruz, Rosa María
author_sort Lagunas-Rangel, Francisco Alejandro
collection PubMed
description Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more DNA repair pathways, therefore, to test different compounds of natural origin that have been shown to induce cell death in cancer cells is paramount. Since natural compounds target components of the DNA repair pathways, they have been shown to promote cancer cells to be resensitized to current treatments. For this and other reasons, natural compounds have aroused great curiosity and several research projects are being developed around the world to establish combined treatments between them and radio or chemotherapy. In this work, we summarize the effects of different natural compounds on the DNA repair mechanisms of cancer cells and emphasize their possible application to re-sensitize these cells.
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spelling pubmed-77109852020-12-15 Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells Lagunas-Rangel, Francisco Alejandro Bermúdez-Cruz, Rosa María Front Oncol Oncology Resistance to current cancer treatments is an important problem that arises through various mechanisms, but one that stands out involves an overexpression of several factors associated with DNA repair. To counteract this type of resistance, different drugs have been developed to affect one or more DNA repair pathways, therefore, to test different compounds of natural origin that have been shown to induce cell death in cancer cells is paramount. Since natural compounds target components of the DNA repair pathways, they have been shown to promote cancer cells to be resensitized to current treatments. For this and other reasons, natural compounds have aroused great curiosity and several research projects are being developed around the world to establish combined treatments between them and radio or chemotherapy. In this work, we summarize the effects of different natural compounds on the DNA repair mechanisms of cancer cells and emphasize their possible application to re-sensitize these cells. Frontiers Media S.A. 2020-11-19 /pmc/articles/PMC7710985/ /pubmed/33330091 http://dx.doi.org/10.3389/fonc.2020.598174 Text en Copyright © 2020 Lagunas-Rangel and Bermúdez-Cruz http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lagunas-Rangel, Francisco Alejandro
Bermúdez-Cruz, Rosa María
Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title_full Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title_fullStr Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title_full_unstemmed Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title_short Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
title_sort natural compounds that target dna repair pathways and their therapeutic potential to counteract cancer cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710985/
https://www.ncbi.nlm.nih.gov/pubmed/33330091
http://dx.doi.org/10.3389/fonc.2020.598174
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