Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity

Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity and pattern are generated by the extension and...

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Detalles Bibliográficos
Autores principales: Wilkes, Oliver R., Moore, Adrian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711044/
https://www.ncbi.nlm.nih.gov/pubmed/33328893
http://dx.doi.org/10.3389/fncel.2020.594199
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author Wilkes, Oliver R.
Moore, Adrian W.
author_facet Wilkes, Oliver R.
Moore, Adrian W.
author_sort Wilkes, Oliver R.
collection PubMed
description Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity and pattern are generated by the extension and organization of these arrays. We describe how several molecularly distinct microtubule organizing center (MTOC) mechanisms function during neuron differentiation to generate and arrange dendrite and axon microtubules. The temporal and spatial organization of these MTOCs generates, patterns, and diversifies arbor wiring.
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spelling pubmed-77110442020-12-15 Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity Wilkes, Oliver R. Moore, Adrian W. Front Cell Neurosci Neuroscience Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity and pattern are generated by the extension and organization of these arrays. We describe how several molecularly distinct microtubule organizing center (MTOC) mechanisms function during neuron differentiation to generate and arrange dendrite and axon microtubules. The temporal and spatial organization of these MTOCs generates, patterns, and diversifies arbor wiring. Frontiers Media S.A. 2020-11-19 /pmc/articles/PMC7711044/ /pubmed/33328893 http://dx.doi.org/10.3389/fncel.2020.594199 Text en Copyright © 2020 Wilkes and Moore. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wilkes, Oliver R.
Moore, Adrian W.
Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title_full Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title_fullStr Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title_full_unstemmed Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title_short Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity
title_sort distinct microtubule organizing center mechanisms combine to generate neuron polarity and arbor complexity
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711044/
https://www.ncbi.nlm.nih.gov/pubmed/33328893
http://dx.doi.org/10.3389/fncel.2020.594199
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