Invasive ductal carcinoma arising in borderline phyllode tumor: A potential role of PIK3CA mutation

INTRODUCTION: Carcinomatous lesions associated with phyllodes tumors are extremely rare and are found in less than 1% of all cases. To date, the molecular biological mechanisms associated with this carcinomatous transformation remain unknown. PRESENTATION OF CASE: We present here the case of a 61-ye...

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Detalles Bibliográficos
Autores principales: Bouri, Sarah, Simon, Philippe, D’Haene, Nicky, Catteau, Xavier, Noël, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711183/
https://www.ncbi.nlm.nih.gov/pubmed/33395878
http://dx.doi.org/10.1016/j.ijscr.2020.10.134
Descripción
Sumario:INTRODUCTION: Carcinomatous lesions associated with phyllodes tumors are extremely rare and are found in less than 1% of all cases. To date, the molecular biological mechanisms associated with this carcinomatous transformation remain unknown. PRESENTATION OF CASE: We present here the case of a 61-year-old patient with invasive ductal of no special type (NST) carcinoma originating in a borderline phyllode tumor with mutation in the PIK3CA gene. DISCUSSION: To the best of our knowledge, this mutation has never been described in this type of association. CONCLUSION: Based on these data, we can better understand the ethiopathogenic molecular mechanisms in this type of lesion. Consequently, they could also in the future give rise to new therapeutic alternatives.

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