Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptomatic, yet highly infectious and readily transmit vi...

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Detalles Bibliográficos
Autores principales: Proud, Pamela C., Tsitoura, Daphne, Watson, Robert J., Chua, Brendon Y., Aram, Marilyn J., Bewley, Kevin R., Cavell, Breeze E., Cobb, Rebecca, Dowall, Stuart, Fotheringham, Susan A., Ho, Catherine M.K., Lucas, Vanessa, Ngabo, Didier, Rayner, Emma, Ryan, Kathryn A., Slack, Gillian S., Thomas, Stephen, Wand, Nadina I., Yeates, Paul, Demaison, Christophe, Zeng, Weiguang, Holmes, Ian, Jackson, David C., Bartlett, Nathan W., Mercuri, Francesca, Carroll, Miles W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711201/
https://www.ncbi.nlm.nih.gov/pubmed/33279857
http://dx.doi.org/10.1016/j.ebiom.2020.103153

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