Changing paradigm in advanced and metastatic non-small cell lung cancer

Lung cancer is the most common cancer worldwide. Approximately 18% of all deaths related to cancer are associated with lung cancer. Management of non-small cell lung cancer (NSCLC) has been changing rapidly in last few years. For patients with unresectable non-metastatic disease, maintenance durvalu...

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Autores principales: Uprety, Dipesh, Parikh, Kaushal, Sawkar, Anita, Dimou, Anastasios, Leventakos, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Review Article on Contemporary Practice in Thoracic Neoplasm Diagnosis, Evaluation and Treatment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711369/
https://www.ncbi.nlm.nih.gov/pubmed/33282404
http://dx.doi.org/10.21037/jtd-20-1472
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author Uprety, Dipesh
Parikh, Kaushal
Sawkar, Anita
Dimou, Anastasios
Leventakos, Konstantinos
author_facet Uprety, Dipesh
Parikh, Kaushal
Sawkar, Anita
Dimou, Anastasios
Leventakos, Konstantinos
author_sort Uprety, Dipesh
collection PubMed
description Lung cancer is the most common cancer worldwide. Approximately 18% of all deaths related to cancer are associated with lung cancer. Management of non-small cell lung cancer (NSCLC) has been changing rapidly in last few years. For patients with unresectable non-metastatic disease, maintenance durvalumab is now given after offering chemo-radiation concurrently based on the result from the PACIFIC trial. Management of metastatic disease greatly depends on the status of sensitizing driver mutation and PD-L1 level of the tumor cells. In this review article, we will summarize the outcome of various clinical trials and will provide the most up-to-date information on the management of patients with advanced and metastatic NSCLC.
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spelling pubmed-77113692020-12-03 Changing paradigm in advanced and metastatic non-small cell lung cancer Uprety, Dipesh Parikh, Kaushal Sawkar, Anita Dimou, Anastasios Leventakos, Konstantinos J Thorac Dis Review Article on Contemporary Practice in Thoracic Neoplasm Diagnosis, Evaluation and Treatment Lung cancer is the most common cancer worldwide. Approximately 18% of all deaths related to cancer are associated with lung cancer. Management of non-small cell lung cancer (NSCLC) has been changing rapidly in last few years. For patients with unresectable non-metastatic disease, maintenance durvalumab is now given after offering chemo-radiation concurrently based on the result from the PACIFIC trial. Management of metastatic disease greatly depends on the status of sensitizing driver mutation and PD-L1 level of the tumor cells. In this review article, we will summarize the outcome of various clinical trials and will provide the most up-to-date information on the management of patients with advanced and metastatic NSCLC. AME Publishing Company 2020-11 /pmc/articles/PMC7711369/ /pubmed/33282404 http://dx.doi.org/10.21037/jtd-20-1472 Text en 2020 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Article on Contemporary Practice in Thoracic Neoplasm Diagnosis, Evaluation and Treatment
Uprety, Dipesh
Parikh, Kaushal
Sawkar, Anita
Dimou, Anastasios
Leventakos, Konstantinos
Changing paradigm in advanced and metastatic non-small cell lung cancer
title Changing paradigm in advanced and metastatic non-small cell lung cancer
title_full Changing paradigm in advanced and metastatic non-small cell lung cancer
title_fullStr Changing paradigm in advanced and metastatic non-small cell lung cancer
title_full_unstemmed Changing paradigm in advanced and metastatic non-small cell lung cancer
title_short Changing paradigm in advanced and metastatic non-small cell lung cancer
title_sort changing paradigm in advanced and metastatic non-small cell lung cancer
topic Review Article on Contemporary Practice in Thoracic Neoplasm Diagnosis, Evaluation and Treatment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711369/
https://www.ncbi.nlm.nih.gov/pubmed/33282404
http://dx.doi.org/10.21037/jtd-20-1472
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