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Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study

The efficacy of hemoperfusion (HP) in patients with acute paraquat poisoning (PQ) remains controversial. We conducted a multi-center retrospective study to include acute PQ-poisoned patients admitted to two tertiary medical centers between 2005 and 2015. We used the Severity Index of Paraquat Poison...

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Autores principales: Yeh, Ying-Tse, Chen, Chun-Kuei, Lin, Chih-Chuan, Chang, Chia-Ming, Lan, Kai-Ping, How, Chorng-Kuang, Yen, Hung-Tsang, Chen, Yen-Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711471/
https://www.ncbi.nlm.nih.gov/pubmed/33050540
http://dx.doi.org/10.3390/toxics8040084
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author Yeh, Ying-Tse
Chen, Chun-Kuei
Lin, Chih-Chuan
Chang, Chia-Ming
Lan, Kai-Ping
How, Chorng-Kuang
Yen, Hung-Tsang
Chen, Yen-Chia
author_facet Yeh, Ying-Tse
Chen, Chun-Kuei
Lin, Chih-Chuan
Chang, Chia-Ming
Lan, Kai-Ping
How, Chorng-Kuang
Yen, Hung-Tsang
Chen, Yen-Chia
author_sort Yeh, Ying-Tse
collection PubMed
description The efficacy of hemoperfusion (HP) in patients with acute paraquat poisoning (PQ) remains controversial. We conducted a multi-center retrospective study to include acute PQ-poisoned patients admitted to two tertiary medical centers between 2005 and 2015. We used the Severity Index of Paraquat Poisoning (SIPP) to stratify the severity of PQ-poisoned patients. The indication to start HP was a positive result for the semiquantitative urine PQ test and presentation to the hospital was within 24 h. Early HP was defined as the first session of HP performed within five hours of PQ ingestion. A total of 213 patients (100 HP group, 113 non-HP group) were eligible for the study. The overall 60-day mortality of poisoned patients was 75.6% (161/213). Multivariate Cox regression analysis showed no statistically significant difference in 60-day survival between HP and non-HP groups (95% confidence interval (CI): 0.84–1.63, p = 0.363). Further subgroup analysis in the HP group showed early HP (95% CI: 0.54–1.69, p = 0.880), and multiple secessions of HP (95% CI: 0.56–1.07, p = 0.124) were not significantly related to better survival. Among acute PQ-poisoned patients, this study found that HP was not associated with increased 60-day survival. Furthermore, neither early HP nor multiple secessions of HP were associated with survival.
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spelling pubmed-77114712020-12-04 Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study Yeh, Ying-Tse Chen, Chun-Kuei Lin, Chih-Chuan Chang, Chia-Ming Lan, Kai-Ping How, Chorng-Kuang Yen, Hung-Tsang Chen, Yen-Chia Toxics Article The efficacy of hemoperfusion (HP) in patients with acute paraquat poisoning (PQ) remains controversial. We conducted a multi-center retrospective study to include acute PQ-poisoned patients admitted to two tertiary medical centers between 2005 and 2015. We used the Severity Index of Paraquat Poisoning (SIPP) to stratify the severity of PQ-poisoned patients. The indication to start HP was a positive result for the semiquantitative urine PQ test and presentation to the hospital was within 24 h. Early HP was defined as the first session of HP performed within five hours of PQ ingestion. A total of 213 patients (100 HP group, 113 non-HP group) were eligible for the study. The overall 60-day mortality of poisoned patients was 75.6% (161/213). Multivariate Cox regression analysis showed no statistically significant difference in 60-day survival between HP and non-HP groups (95% confidence interval (CI): 0.84–1.63, p = 0.363). Further subgroup analysis in the HP group showed early HP (95% CI: 0.54–1.69, p = 0.880), and multiple secessions of HP (95% CI: 0.56–1.07, p = 0.124) were not significantly related to better survival. Among acute PQ-poisoned patients, this study found that HP was not associated with increased 60-day survival. Furthermore, neither early HP nor multiple secessions of HP were associated with survival. MDPI 2020-10-10 /pmc/articles/PMC7711471/ /pubmed/33050540 http://dx.doi.org/10.3390/toxics8040084 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yeh, Ying-Tse
Chen, Chun-Kuei
Lin, Chih-Chuan
Chang, Chia-Ming
Lan, Kai-Ping
How, Chorng-Kuang
Yen, Hung-Tsang
Chen, Yen-Chia
Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title_full Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title_fullStr Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title_full_unstemmed Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title_short Does Hemoperfusion Increase Survival in Acute Paraquat Poisoning? A Retrospective Multicenter Study
title_sort does hemoperfusion increase survival in acute paraquat poisoning? a retrospective multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711471/
https://www.ncbi.nlm.nih.gov/pubmed/33050540
http://dx.doi.org/10.3390/toxics8040084
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