Cargando…
Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study
Although Candida species remain the leading cause of invasive fungal infections (IFI), the list of other isolated fungal pathogens is increasing. The aim of the study was to report cases of IFI caused by rare yeasts in the largest tertiary Greek pediatric hospital. A retrospective study was performe...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711555/ https://www.ncbi.nlm.nih.gov/pubmed/32998455 http://dx.doi.org/10.3390/jof6040194 |
_version_ | 1783618173369581568 |
---|---|
author | Noni, Maria Stathi, Angeliki Velegraki, Aristea Malamati, Mika Kalampaliki, Alexandra Zachariadou, Levantia Michos, Athanasios |
author_facet | Noni, Maria Stathi, Angeliki Velegraki, Aristea Malamati, Mika Kalampaliki, Alexandra Zachariadou, Levantia Michos, Athanasios |
author_sort | Noni, Maria |
collection | PubMed |
description | Although Candida species remain the leading cause of invasive fungal infections (IFI), the list of other isolated fungal pathogens is increasing. The aim of the study was to report cases of IFI caused by rare yeasts in the largest tertiary Greek pediatric hospital. A retrospective study was performed from 6/2008–6/2020 regarding IFI caused by rare species. Identification of isolates was attained by conventional, molecular, and MALDI TOF MS methods, and susceptibility testing was performed according to the Clinical and Laboratory Standards (CLSI) methodology. During a 12-year period, 14 different rare fungal species in 33 neonates and children with IFI hospitalized in intensive care and oncology units were isolated from blood, central catheters, peritoneal, pleural, or pericardial fluid specimens. It is the first time for IFI caused by Wickerhamomyces anomalus (Candida pelliculosa), Pichia fermentans (Candida lambica), Yarrowia (Candida) lipolytica, Pichia (Hansenula) kluyveri, Rhodotorula mucilaginosa, Wickerhamiella (Candida) pararugosa and Cyberlindnera (Candida) fabianii in Greek neonates and children to be reported. For most of these rare fungal species isolated in the present study, no official antifungal breakpoints have been defined, and there are no guidelines for their treatment. Clinical laboratories should be aware of uncommon and emerging yeast pathogens and be able to detect them with molecular and proteomic methods. |
format | Online Article Text |
id | pubmed-7711555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77115552020-12-04 Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study Noni, Maria Stathi, Angeliki Velegraki, Aristea Malamati, Mika Kalampaliki, Alexandra Zachariadou, Levantia Michos, Athanasios J Fungi (Basel) Article Although Candida species remain the leading cause of invasive fungal infections (IFI), the list of other isolated fungal pathogens is increasing. The aim of the study was to report cases of IFI caused by rare yeasts in the largest tertiary Greek pediatric hospital. A retrospective study was performed from 6/2008–6/2020 regarding IFI caused by rare species. Identification of isolates was attained by conventional, molecular, and MALDI TOF MS methods, and susceptibility testing was performed according to the Clinical and Laboratory Standards (CLSI) methodology. During a 12-year period, 14 different rare fungal species in 33 neonates and children with IFI hospitalized in intensive care and oncology units were isolated from blood, central catheters, peritoneal, pleural, or pericardial fluid specimens. It is the first time for IFI caused by Wickerhamomyces anomalus (Candida pelliculosa), Pichia fermentans (Candida lambica), Yarrowia (Candida) lipolytica, Pichia (Hansenula) kluyveri, Rhodotorula mucilaginosa, Wickerhamiella (Candida) pararugosa and Cyberlindnera (Candida) fabianii in Greek neonates and children to be reported. For most of these rare fungal species isolated in the present study, no official antifungal breakpoints have been defined, and there are no guidelines for their treatment. Clinical laboratories should be aware of uncommon and emerging yeast pathogens and be able to detect them with molecular and proteomic methods. MDPI 2020-09-28 /pmc/articles/PMC7711555/ /pubmed/32998455 http://dx.doi.org/10.3390/jof6040194 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Noni, Maria Stathi, Angeliki Velegraki, Aristea Malamati, Mika Kalampaliki, Alexandra Zachariadou, Levantia Michos, Athanasios Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title | Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title_full | Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title_fullStr | Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title_full_unstemmed | Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title_short | Rare Invasive Yeast Infections in Greek Neonates and Children, a Retrospective 12-Year Study |
title_sort | rare invasive yeast infections in greek neonates and children, a retrospective 12-year study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711555/ https://www.ncbi.nlm.nih.gov/pubmed/32998455 http://dx.doi.org/10.3390/jof6040194 |
work_keys_str_mv | AT nonimaria rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT stathiangeliki rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT velegrakiaristea rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT malamatimika rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT kalampalikialexandra rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT zachariadoulevantia rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy AT michosathanasios rareinvasiveyeastinfectionsingreekneonatesandchildrenaretrospective12yearstudy |