Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges

(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-ce...

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Autores principales: Shankar, Ananth, Bomanji, Jamshed, Hyare, Harpreet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711629/
https://www.ncbi.nlm.nih.gov/pubmed/33182433
http://dx.doi.org/10.3390/jpm10040218
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author Shankar, Ananth
Bomanji, Jamshed
Hyare, Harpreet
author_facet Shankar, Ananth
Bomanji, Jamshed
Hyare, Harpreet
author_sort Shankar, Ananth
collection PubMed
description (1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of (18)F-fluorocholine (FCho) and (18)fluoro-L-phenylalanine (FDOPA) PET–MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET–MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET–MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours.
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spelling pubmed-77116292020-12-04 Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges Shankar, Ananth Bomanji, Jamshed Hyare, Harpreet J Pers Med Article (1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of (18)F-fluorocholine (FCho) and (18)fluoro-L-phenylalanine (FDOPA) PET–MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET–MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET–MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours. MDPI 2020-11-09 /pmc/articles/PMC7711629/ /pubmed/33182433 http://dx.doi.org/10.3390/jpm10040218 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shankar, Ananth
Bomanji, Jamshed
Hyare, Harpreet
Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title_full Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title_fullStr Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title_full_unstemmed Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title_short Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges
title_sort hybrid pet–mri imaging in paediatric and tya brain tumours: clinical applications and challenges
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711629/
https://www.ncbi.nlm.nih.gov/pubmed/33182433
http://dx.doi.org/10.3390/jpm10040218
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AT hyareharpreet hybridpetmriimaginginpaediatricandtyabraintumoursclinicalapplicationsandchallenges

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