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Latin American Genes: The Great Forgotten in Rheumatoid Arthritis

The successful implementation of personalized medicine will rely on the integration of information obtained at the level of populations with the specific biological, genetic, and clinical characteristics of an individual. However, because genome-wide association studies tend to focus on populations...

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Autores principales: Díaz-Peña, Roberto, Quiñones, Luis A., Castro-Santos, Patricia, Durán, Josefina, Lucia, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711650/
https://www.ncbi.nlm.nih.gov/pubmed/33114702
http://dx.doi.org/10.3390/jpm10040196
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author Díaz-Peña, Roberto
Quiñones, Luis A.
Castro-Santos, Patricia
Durán, Josefina
Lucia, Alejandro
author_facet Díaz-Peña, Roberto
Quiñones, Luis A.
Castro-Santos, Patricia
Durán, Josefina
Lucia, Alejandro
author_sort Díaz-Peña, Roberto
collection PubMed
description The successful implementation of personalized medicine will rely on the integration of information obtained at the level of populations with the specific biological, genetic, and clinical characteristics of an individual. However, because genome-wide association studies tend to focus on populations of European descent, there is a wide gap to bridge between Caucasian and non-Caucasian populations before personalized medicine can be fully implemented, and rheumatoid arthritis (RA) is not an exception. In this review, we discuss advances in our understanding of genetic determinants of RA risk among global populations, with a focus on the Latin American population. Geographically restricted genetic diversity may have important implications for health and disease that will remain unknown until genetic association studies have been extended to include Latin American and other currently under-represented ancestries. The next few years will witness many breakthroughs in personalized medicine, including applications for common diseases and risk stratification instruments for targeted prevention/intervention strategies. Not all of these applications may be extrapolated from the Caucasian experience to Latin American or other under-represented populations.
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spelling pubmed-77116502020-12-04 Latin American Genes: The Great Forgotten in Rheumatoid Arthritis Díaz-Peña, Roberto Quiñones, Luis A. Castro-Santos, Patricia Durán, Josefina Lucia, Alejandro J Pers Med Review The successful implementation of personalized medicine will rely on the integration of information obtained at the level of populations with the specific biological, genetic, and clinical characteristics of an individual. However, because genome-wide association studies tend to focus on populations of European descent, there is a wide gap to bridge between Caucasian and non-Caucasian populations before personalized medicine can be fully implemented, and rheumatoid arthritis (RA) is not an exception. In this review, we discuss advances in our understanding of genetic determinants of RA risk among global populations, with a focus on the Latin American population. Geographically restricted genetic diversity may have important implications for health and disease that will remain unknown until genetic association studies have been extended to include Latin American and other currently under-represented ancestries. The next few years will witness many breakthroughs in personalized medicine, including applications for common diseases and risk stratification instruments for targeted prevention/intervention strategies. Not all of these applications may be extrapolated from the Caucasian experience to Latin American or other under-represented populations. MDPI 2020-10-26 /pmc/articles/PMC7711650/ /pubmed/33114702 http://dx.doi.org/10.3390/jpm10040196 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Díaz-Peña, Roberto
Quiñones, Luis A.
Castro-Santos, Patricia
Durán, Josefina
Lucia, Alejandro
Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title_full Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title_fullStr Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title_full_unstemmed Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title_short Latin American Genes: The Great Forgotten in Rheumatoid Arthritis
title_sort latin american genes: the great forgotten in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711650/
https://www.ncbi.nlm.nih.gov/pubmed/33114702
http://dx.doi.org/10.3390/jpm10040196
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