A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proli...

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Detalles Bibliográficos
Autores principales: Cohen, Jeffrey E., Goldstone, Andrew B., Wang, Hanjay, Purcell, Brendan P., Shudo, Yasuhiro, MacArthur, John W., Steele, Amanda N., Paulsen, Michael J., Edwards, Bryan B., Aribeana, Chiaka N., Cheung, Nicholas C., Burdick, Jason A., Woo, Y. Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711763/
https://www.ncbi.nlm.nih.gov/pubmed/33212844
http://dx.doi.org/10.3390/jcdd7040053

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