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Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network
Chromoblastomycosis (CBM) is a neglected implantation mycosis prevalent in tropical climate zones, considered an occupational disease that affects impoverished rural populations. This retrospective study described clinical aspects of CBM in a hyperendemic area in Brazil and constructed a worldwide h...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711792/ https://www.ncbi.nlm.nih.gov/pubmed/33022951 http://dx.doi.org/10.3390/jof6040204 |
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author | Santos, Daniel Wagner C. L. Vicente, Vania Aparecida Weiss, Vinicius Almir de Hoog, G. Sybren Gomes, Renata R. Batista, Edith M. M. Marques, Sirlei Garcia de Queiroz-Telles, Flávio Colombo, Arnaldo Lopes de Azevedo, Conceição de Maria Pedrozo e Silva |
author_facet | Santos, Daniel Wagner C. L. Vicente, Vania Aparecida Weiss, Vinicius Almir de Hoog, G. Sybren Gomes, Renata R. Batista, Edith M. M. Marques, Sirlei Garcia de Queiroz-Telles, Flávio Colombo, Arnaldo Lopes de Azevedo, Conceição de Maria Pedrozo e Silva |
author_sort | Santos, Daniel Wagner C. L. |
collection | PubMed |
description | Chromoblastomycosis (CBM) is a neglected implantation mycosis prevalent in tropical climate zones, considered an occupational disease that affects impoverished rural populations. This retrospective study described clinical aspects of CBM in a hyperendemic area in Brazil and constructed a worldwide haplotype network of Fonsecaea spp. strains. The variables were collected from medical records using a standard report form, reporting 191 patients with CBM from Maranhão, Brazil. The mean age was 56.1 years, 168 (88%) patients were male and predominantly farmers (85.8%). The mean time of evolution of the disease until diagnosis was 9.4 years. Lower limbs (81.2%) and upper limbs (14.2%) were the main sites affected. Most patients exhibited verrucous (55%) and infiltrative plaque (48.2%). Fonsecaea spp. were identified in 136 cases and a haplotype network constructed with ITS sequences of 185 global strains revealed a total of 59 haplotypes exhibiting high haplotypic and low nucleotide diversities. No correlation was observed between the different haplotypes of Fonsecaea species and dermatological patterns, severity of disease or geographic distribution inside Maranhão. Data from this area contributed to better understanding the epidemiology of CBM. For the first time, a robust haplotype network with Fonsecaea strains reveals an evolutionary history with a recent population expansion. |
format | Online Article Text |
id | pubmed-7711792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77117922020-12-04 Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network Santos, Daniel Wagner C. L. Vicente, Vania Aparecida Weiss, Vinicius Almir de Hoog, G. Sybren Gomes, Renata R. Batista, Edith M. M. Marques, Sirlei Garcia de Queiroz-Telles, Flávio Colombo, Arnaldo Lopes de Azevedo, Conceição de Maria Pedrozo e Silva J Fungi (Basel) Article Chromoblastomycosis (CBM) is a neglected implantation mycosis prevalent in tropical climate zones, considered an occupational disease that affects impoverished rural populations. This retrospective study described clinical aspects of CBM in a hyperendemic area in Brazil and constructed a worldwide haplotype network of Fonsecaea spp. strains. The variables were collected from medical records using a standard report form, reporting 191 patients with CBM from Maranhão, Brazil. The mean age was 56.1 years, 168 (88%) patients were male and predominantly farmers (85.8%). The mean time of evolution of the disease until diagnosis was 9.4 years. Lower limbs (81.2%) and upper limbs (14.2%) were the main sites affected. Most patients exhibited verrucous (55%) and infiltrative plaque (48.2%). Fonsecaea spp. were identified in 136 cases and a haplotype network constructed with ITS sequences of 185 global strains revealed a total of 59 haplotypes exhibiting high haplotypic and low nucleotide diversities. No correlation was observed between the different haplotypes of Fonsecaea species and dermatological patterns, severity of disease or geographic distribution inside Maranhão. Data from this area contributed to better understanding the epidemiology of CBM. For the first time, a robust haplotype network with Fonsecaea strains reveals an evolutionary history with a recent population expansion. MDPI 2020-10-03 /pmc/articles/PMC7711792/ /pubmed/33022951 http://dx.doi.org/10.3390/jof6040204 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Santos, Daniel Wagner C. L. Vicente, Vania Aparecida Weiss, Vinicius Almir de Hoog, G. Sybren Gomes, Renata R. Batista, Edith M. M. Marques, Sirlei Garcia de Queiroz-Telles, Flávio Colombo, Arnaldo Lopes de Azevedo, Conceição de Maria Pedrozo e Silva Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title | Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title_full | Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title_fullStr | Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title_full_unstemmed | Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title_short | Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network |
title_sort | chromoblastomycosis in an endemic area of brazil: a clinical-epidemiological analysis and a worldwide haplotype network |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711792/ https://www.ncbi.nlm.nih.gov/pubmed/33022951 http://dx.doi.org/10.3390/jof6040204 |
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