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Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes
Juvenile hormone has been suggested to be a potential mediator in the trade-off between mating and insects’ immunity. Studies on various insect taxons have found that juvenile hormone interferes with humoral and cellular immunity. Although this was shown experimentally, studies using highly virulent...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711818/ https://www.ncbi.nlm.nih.gov/pubmed/33227937 http://dx.doi.org/10.3390/jof6040298 |
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author | Rantala, Markus J. Dubovskiy, Ivan M. Pölkki, Mari Krama, Tatjana Contreras-Garduño, Jorge Krams, Indrikis A. |
author_facet | Rantala, Markus J. Dubovskiy, Ivan M. Pölkki, Mari Krama, Tatjana Contreras-Garduño, Jorge Krams, Indrikis A. |
author_sort | Rantala, Markus J. |
collection | PubMed |
description | Juvenile hormone has been suggested to be a potential mediator in the trade-off between mating and insects’ immunity. Studies on various insect taxons have found that juvenile hormone interferes with humoral and cellular immunity. Although this was shown experimentally, studies using highly virulent parasites or pathogens are lacking so far. In this study, we tested if juvenile hormone administration affected resistance against entomopathogenic fungi, Metarhizium robertsii, in the mealworm beetle, Tenebrio molitor. In previous studies with T. molitor, juvenile hormone has been found to reduce a major humoral immune effector-system (phenoloxidase) in both sexes and decrease the encapsulation response in males. Here, we found that juvenile hormone administration prolonged survival time after infection with M. robertsii in males but reduced survival time in females. This study indicates that the effects of juvenile hormone on insect immunity might be more complicated than previously considered. We also suggest that there might be a trade-off between specific and non-specific immunity since, in males, juvenile hormone enhances specific immunity but corrupts non-specific immunity. Our study highlights the importance of using real parasites and pathogens in immuno-ecological studies. |
format | Online Article Text |
id | pubmed-7711818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77118182020-12-04 Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes Rantala, Markus J. Dubovskiy, Ivan M. Pölkki, Mari Krama, Tatjana Contreras-Garduño, Jorge Krams, Indrikis A. J Fungi (Basel) Article Juvenile hormone has been suggested to be a potential mediator in the trade-off between mating and insects’ immunity. Studies on various insect taxons have found that juvenile hormone interferes with humoral and cellular immunity. Although this was shown experimentally, studies using highly virulent parasites or pathogens are lacking so far. In this study, we tested if juvenile hormone administration affected resistance against entomopathogenic fungi, Metarhizium robertsii, in the mealworm beetle, Tenebrio molitor. In previous studies with T. molitor, juvenile hormone has been found to reduce a major humoral immune effector-system (phenoloxidase) in both sexes and decrease the encapsulation response in males. Here, we found that juvenile hormone administration prolonged survival time after infection with M. robertsii in males but reduced survival time in females. This study indicates that the effects of juvenile hormone on insect immunity might be more complicated than previously considered. We also suggest that there might be a trade-off between specific and non-specific immunity since, in males, juvenile hormone enhances specific immunity but corrupts non-specific immunity. Our study highlights the importance of using real parasites and pathogens in immuno-ecological studies. MDPI 2020-11-19 /pmc/articles/PMC7711818/ /pubmed/33227937 http://dx.doi.org/10.3390/jof6040298 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rantala, Markus J. Dubovskiy, Ivan M. Pölkki, Mari Krama, Tatjana Contreras-Garduño, Jorge Krams, Indrikis A. Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title | Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title_full | Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title_fullStr | Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title_full_unstemmed | Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title_short | Effect of Juvenile Hormone on Resistance against Entomopathogenic Fungus Metarhizium robertsii Differs between Sexes |
title_sort | effect of juvenile hormone on resistance against entomopathogenic fungus metarhizium robertsii differs between sexes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711818/ https://www.ncbi.nlm.nih.gov/pubmed/33227937 http://dx.doi.org/10.3390/jof6040298 |
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