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Cell Scaffolds for Bone Tissue Engineering

Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft transplantation. However, they are often risky pro...

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Detalles Bibliográficos
Autores principales: Iijima, Kazutoshi, Otsuka, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711861/
https://www.ncbi.nlm.nih.gov/pubmed/33007995
http://dx.doi.org/10.3390/bioengineering7040119
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author Iijima, Kazutoshi
Otsuka, Hidenori
author_facet Iijima, Kazutoshi
Otsuka, Hidenori
author_sort Iijima, Kazutoshi
collection PubMed
description Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft transplantation. However, they are often risky procedures and related to postoperative complications. As an alternative, tissue engineering to regenerate new bone often involves the use of mesenchymal stem cells (MSCs), derived from bone marrow, adipose tissues, and so on, which are cultured into three-dimensional (3D) scaffolds to regenerate bone tissue by osteoinductive signaling. In this manuscript, we provide an overview of recent treatment of bone defects and the studies on the creation of cell scaffolds for bone regeneration. Bone regeneration from bone marrow-derived mesenchymal stem cells using silica nonwoven fabric by the authors’ group were provided. Potential application and future direction of the present systems were also described.
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spelling pubmed-77118612020-12-04 Cell Scaffolds for Bone Tissue Engineering Iijima, Kazutoshi Otsuka, Hidenori Bioengineering (Basel) Perspective Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft transplantation. However, they are often risky procedures and related to postoperative complications. As an alternative, tissue engineering to regenerate new bone often involves the use of mesenchymal stem cells (MSCs), derived from bone marrow, adipose tissues, and so on, which are cultured into three-dimensional (3D) scaffolds to regenerate bone tissue by osteoinductive signaling. In this manuscript, we provide an overview of recent treatment of bone defects and the studies on the creation of cell scaffolds for bone regeneration. Bone regeneration from bone marrow-derived mesenchymal stem cells using silica nonwoven fabric by the authors’ group were provided. Potential application and future direction of the present systems were also described. MDPI 2020-09-30 /pmc/articles/PMC7711861/ /pubmed/33007995 http://dx.doi.org/10.3390/bioengineering7040119 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Iijima, Kazutoshi
Otsuka, Hidenori
Cell Scaffolds for Bone Tissue Engineering
title Cell Scaffolds for Bone Tissue Engineering
title_full Cell Scaffolds for Bone Tissue Engineering
title_fullStr Cell Scaffolds for Bone Tissue Engineering
title_full_unstemmed Cell Scaffolds for Bone Tissue Engineering
title_short Cell Scaffolds for Bone Tissue Engineering
title_sort cell scaffolds for bone tissue engineering
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711861/
https://www.ncbi.nlm.nih.gov/pubmed/33007995
http://dx.doi.org/10.3390/bioengineering7040119
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