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Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?

The burden of aspergillosis, especially Chronic Pulmonary Aspergillosis, is increasingly recognized, and the increasing presence of azole-resistant environmental Aspergillus fumigatus has been highlighted as a health risk. However, a sizable minority of aspergillosis is caused by Aspergillus flavus,...

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Autores principales: Duong, Tra My N., Nguyen, Phuong Tuyen, Le, Thanh Van, Nguyen, Huong Lan P., Nguyen, Bich Ngoc T., Nguyen, Bich Phuong T., Nguyen, Thu Anh, Chen, Sharon C.-A., Barrs, Vanessa R., Halliday, Catriona L., Sorrell, Tania C., Day, Jeremy N., Beardsley, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711995/
https://www.ncbi.nlm.nih.gov/pubmed/33217930
http://dx.doi.org/10.3390/jof6040296
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author Duong, Tra My N.
Nguyen, Phuong Tuyen
Le, Thanh Van
Nguyen, Huong Lan P.
Nguyen, Bich Ngoc T.
Nguyen, Bich Phuong T.
Nguyen, Thu Anh
Chen, Sharon C.-A.
Barrs, Vanessa R.
Halliday, Catriona L.
Sorrell, Tania C.
Day, Jeremy N.
Beardsley, Justin
author_facet Duong, Tra My N.
Nguyen, Phuong Tuyen
Le, Thanh Van
Nguyen, Huong Lan P.
Nguyen, Bich Ngoc T.
Nguyen, Bich Phuong T.
Nguyen, Thu Anh
Chen, Sharon C.-A.
Barrs, Vanessa R.
Halliday, Catriona L.
Sorrell, Tania C.
Day, Jeremy N.
Beardsley, Justin
author_sort Duong, Tra My N.
collection PubMed
description The burden of aspergillosis, especially Chronic Pulmonary Aspergillosis, is increasingly recognized, and the increasing presence of azole-resistant environmental Aspergillus fumigatus has been highlighted as a health risk. However, a sizable minority of aspergillosis is caused by Aspergillus flavus, which is assumed to be sensitive to azoles but is infrequently included in surveillance. We conducted environmental sampling at 150 locations in a rural province of southern Vietnam. A. flavus isolates were identified morphologically, their identity was confirmed by sequencing of the beta-tubulin gene, and then they were tested for susceptibility to azoles and amphotericin B according to EUCAST methodologies. We found that over 85% of A. flavus isolates were resistant to at least one azole, and half of them were resistant to itraconazole. This unexpectedly high prevalence of resistance demands further investigation to determine whether it is linked to agricultural azole use, as has been described for A. fumigatus. Clinical correlation is required, so that guidelines can be adjusted to take this information into account.
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spelling pubmed-77119952020-12-04 Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis? Duong, Tra My N. Nguyen, Phuong Tuyen Le, Thanh Van Nguyen, Huong Lan P. Nguyen, Bich Ngoc T. Nguyen, Bich Phuong T. Nguyen, Thu Anh Chen, Sharon C.-A. Barrs, Vanessa R. Halliday, Catriona L. Sorrell, Tania C. Day, Jeremy N. Beardsley, Justin J Fungi (Basel) Communication The burden of aspergillosis, especially Chronic Pulmonary Aspergillosis, is increasingly recognized, and the increasing presence of azole-resistant environmental Aspergillus fumigatus has been highlighted as a health risk. However, a sizable minority of aspergillosis is caused by Aspergillus flavus, which is assumed to be sensitive to azoles but is infrequently included in surveillance. We conducted environmental sampling at 150 locations in a rural province of southern Vietnam. A. flavus isolates were identified morphologically, their identity was confirmed by sequencing of the beta-tubulin gene, and then they were tested for susceptibility to azoles and amphotericin B according to EUCAST methodologies. We found that over 85% of A. flavus isolates were resistant to at least one azole, and half of them were resistant to itraconazole. This unexpectedly high prevalence of resistance demands further investigation to determine whether it is linked to agricultural azole use, as has been described for A. fumigatus. Clinical correlation is required, so that guidelines can be adjusted to take this information into account. MDPI 2020-11-18 /pmc/articles/PMC7711995/ /pubmed/33217930 http://dx.doi.org/10.3390/jof6040296 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Duong, Tra My N.
Nguyen, Phuong Tuyen
Le, Thanh Van
Nguyen, Huong Lan P.
Nguyen, Bich Ngoc T.
Nguyen, Bich Phuong T.
Nguyen, Thu Anh
Chen, Sharon C.-A.
Barrs, Vanessa R.
Halliday, Catriona L.
Sorrell, Tania C.
Day, Jeremy N.
Beardsley, Justin
Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title_full Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title_fullStr Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title_full_unstemmed Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title_short Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?
title_sort drug-resistant aspergillus flavus is highly prevalent in the environment of vietnam: a new challenge for the management of aspergillosis?
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711995/
https://www.ncbi.nlm.nih.gov/pubmed/33217930
http://dx.doi.org/10.3390/jof6040296
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