Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis. Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed considerable reactogenicity and were replaced by s...

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Detalles Bibliográficos
Autores principales: Arenas, Jesús, Pupo, Elder, Phielix, Coen, David, Dionne, Zariri, Afshin, Zamyatina, Alla, Tommassen, Jan, van der Ley, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712016/
https://www.ncbi.nlm.nih.gov/pubmed/33050234
http://dx.doi.org/10.3390/vaccines8040594

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