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The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines

Vaccinations are among the most effective medical procedures and have had an incredible impact on almost everyone’s life. One of the populations that can benefit the most from them are elderly people. Unfortunately, in this group, vaccines are less effective than in other groups, due to immunosenesc...

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Autores principales: Cianci, Rossella, Franza, Laura, Massaro, Maria Grazia, Borriello, Raffaele, De Vito, Francesco, Gambassi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712068/
https://www.ncbi.nlm.nih.gov/pubmed/33147686
http://dx.doi.org/10.3390/vaccines8040636
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author Cianci, Rossella
Franza, Laura
Massaro, Maria Grazia
Borriello, Raffaele
De Vito, Francesco
Gambassi, Giovanni
author_facet Cianci, Rossella
Franza, Laura
Massaro, Maria Grazia
Borriello, Raffaele
De Vito, Francesco
Gambassi, Giovanni
author_sort Cianci, Rossella
collection PubMed
description Vaccinations are among the most effective medical procedures and have had an incredible impact on almost everyone’s life. One of the populations that can benefit the most from them are elderly people. Unfortunately, in this group, vaccines are less effective than in other groups, due to immunosenescence. The immune system ages like the whole body and becomes less effective in responding to infections and vaccinations. At the same time, immunosenescence also favors an inflammatory microenvironment, which is linked to many conditions typical of the geriatrics population. The microbiota is one of the key actors in modulating the immune response and, in this review, we discuss the current evidence on the role of microbiota in regulating the immune response to vaccines, particularly in elderly people.
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spelling pubmed-77120682020-12-04 The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines Cianci, Rossella Franza, Laura Massaro, Maria Grazia Borriello, Raffaele De Vito, Francesco Gambassi, Giovanni Vaccines (Basel) Review Vaccinations are among the most effective medical procedures and have had an incredible impact on almost everyone’s life. One of the populations that can benefit the most from them are elderly people. Unfortunately, in this group, vaccines are less effective than in other groups, due to immunosenescence. The immune system ages like the whole body and becomes less effective in responding to infections and vaccinations. At the same time, immunosenescence also favors an inflammatory microenvironment, which is linked to many conditions typical of the geriatrics population. The microbiota is one of the key actors in modulating the immune response and, in this review, we discuss the current evidence on the role of microbiota in regulating the immune response to vaccines, particularly in elderly people. MDPI 2020-11-02 /pmc/articles/PMC7712068/ /pubmed/33147686 http://dx.doi.org/10.3390/vaccines8040636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cianci, Rossella
Franza, Laura
Massaro, Maria Grazia
Borriello, Raffaele
De Vito, Francesco
Gambassi, Giovanni
The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title_full The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title_fullStr The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title_full_unstemmed The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title_short The Interplay between Immunosenescence and Microbiota in the Efficacy of Vaccines
title_sort interplay between immunosenescence and microbiota in the efficacy of vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712068/
https://www.ncbi.nlm.nih.gov/pubmed/33147686
http://dx.doi.org/10.3390/vaccines8040636
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