Cargando…
Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients
Despite the description of several new prognostic markers, colorectal cancer still represents the third most frequent cause of cancer-related death. As immunotherapy is considered a therapeutic alternative in such patients, neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratio (LMR) are hy...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712240/ https://www.ncbi.nlm.nih.gov/pubmed/33081102 http://dx.doi.org/10.3390/jpm10040173 |
_version_ | 1783618329003425792 |
---|---|
author | Fülöp, Zsolt Zoltán Fülöp, Réka Linda Gurzu, Simona Bara, Tivadar Tímár, József Drágus, Emőke Jung, Ioan |
author_facet | Fülöp, Zsolt Zoltán Fülöp, Réka Linda Gurzu, Simona Bara, Tivadar Tímár, József Drágus, Emőke Jung, Ioan |
author_sort | Fülöp, Zsolt Zoltán |
collection | PubMed |
description | Despite the description of several new prognostic markers, colorectal cancer still represents the third most frequent cause of cancer-related death. As immunotherapy is considered a therapeutic alternative in such patients, neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratio (LMR) are hypothesized to provide reliable prognostic information. A retrospective study was conducted on 1052 patients operated on during 2013–2019 in two clinical hospitals from Hungary and Romania. Inclusion criteria targeted patients over 18 years old, diagnosed with rectal cancer, with preoperatively defined NLR and LMR. The overall survival rate, along with clinical and histopathological data, was evaluated. Overall survival was significantly associated with increased NLR (p = 0.03) and decreased LMR (p = 0.04), with cut-off values of 3.11 and 3.39, respectively. The two parameters were inversely correlated (p < 0.0001). There was no statistically significant association between tumor stage and NLR or LMR (p = 0.30, p = 0.06, respectively). The total mesorectal excision was especially obtained in cases with low NLR (p = 0.0005) and high LMR (p = 0.0009) values. A significant association was also seen between preoperative chemoradiotherapy and high NLR (p = 0.0001) and low LMR (p = 0.0001). In patients with rectal cancer, the preoperative values of NLR and LMR can be used as independent prognostic parameters. An NLR value of ≥3.11 can be used to indicate the response to preoperative chemoradiotherapy, but a low chance of sphincter preservation or obtaining a complete TME. Higher values of NLR and lower values of LMR require a more attentive preoperative evaluation of the mesorectum. |
format | Online Article Text |
id | pubmed-7712240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77122402020-12-04 Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients Fülöp, Zsolt Zoltán Fülöp, Réka Linda Gurzu, Simona Bara, Tivadar Tímár, József Drágus, Emőke Jung, Ioan J Pers Med Article Despite the description of several new prognostic markers, colorectal cancer still represents the third most frequent cause of cancer-related death. As immunotherapy is considered a therapeutic alternative in such patients, neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratio (LMR) are hypothesized to provide reliable prognostic information. A retrospective study was conducted on 1052 patients operated on during 2013–2019 in two clinical hospitals from Hungary and Romania. Inclusion criteria targeted patients over 18 years old, diagnosed with rectal cancer, with preoperatively defined NLR and LMR. The overall survival rate, along with clinical and histopathological data, was evaluated. Overall survival was significantly associated with increased NLR (p = 0.03) and decreased LMR (p = 0.04), with cut-off values of 3.11 and 3.39, respectively. The two parameters were inversely correlated (p < 0.0001). There was no statistically significant association between tumor stage and NLR or LMR (p = 0.30, p = 0.06, respectively). The total mesorectal excision was especially obtained in cases with low NLR (p = 0.0005) and high LMR (p = 0.0009) values. A significant association was also seen between preoperative chemoradiotherapy and high NLR (p = 0.0001) and low LMR (p = 0.0001). In patients with rectal cancer, the preoperative values of NLR and LMR can be used as independent prognostic parameters. An NLR value of ≥3.11 can be used to indicate the response to preoperative chemoradiotherapy, but a low chance of sphincter preservation or obtaining a complete TME. Higher values of NLR and lower values of LMR require a more attentive preoperative evaluation of the mesorectum. MDPI 2020-10-16 /pmc/articles/PMC7712240/ /pubmed/33081102 http://dx.doi.org/10.3390/jpm10040173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fülöp, Zsolt Zoltán Fülöp, Réka Linda Gurzu, Simona Bara, Tivadar Tímár, József Drágus, Emőke Jung, Ioan Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title | Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title_full | Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title_fullStr | Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title_full_unstemmed | Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title_short | Prognostic Impact of the Neutrophil-to-Lymphocyte and Lymphocyte-to-Monocyte Ratio, in Patients with Rectal Cancer: A Retrospective Study of 1052 Patients |
title_sort | prognostic impact of the neutrophil-to-lymphocyte and lymphocyte-to-monocyte ratio, in patients with rectal cancer: a retrospective study of 1052 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712240/ https://www.ncbi.nlm.nih.gov/pubmed/33081102 http://dx.doi.org/10.3390/jpm10040173 |
work_keys_str_mv | AT fulopzsoltzoltan prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT fuloprekalinda prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT gurzusimona prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT barativadar prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT timarjozsef prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT dragusemoke prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients AT jungioan prognosticimpactoftheneutrophiltolymphocyteandlymphocytetomonocyteratioinpatientswithrectalcanceraretrospectivestudyof1052patients |