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Analysis of expression and prognosis of KLK7 in ovarian cancer

BACKGROUND: Ovarian cancer is one of the common malignant tumors in female reproductive organs. Kallikrein-related peptidase (KLK) 7 is a secreted serine peptidase that is related to different cancer. To investigate the expression and significance of KLK7 in ovarian cancer. MATERIALS AND METHODS: Th...

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Autores principales: Chen, Erhua, Zhu, Huifang, Yang, Yue, Wang, Ling, Zhang, Jianhua, Han, Yonghong, Liu, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712299/
https://www.ncbi.nlm.nih.gov/pubmed/33336051
http://dx.doi.org/10.1515/med-2020-0139
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author Chen, Erhua
Zhu, Huifang
Yang, Yue
Wang, Ling
Zhang, Jianhua
Han, Yonghong
Liu, Xiang
author_facet Chen, Erhua
Zhu, Huifang
Yang, Yue
Wang, Ling
Zhang, Jianhua
Han, Yonghong
Liu, Xiang
author_sort Chen, Erhua
collection PubMed
description BACKGROUND: Ovarian cancer is one of the common malignant tumors in female reproductive organs. Kallikrein-related peptidase (KLK) 7 is a secreted serine peptidase that is related to different cancer. To investigate the expression and significance of KLK7 in ovarian cancer. MATERIALS AND METHODS: The expression of KLK7 in human ovarian cancer was evaluated by Oncomine and Cancer Cell Line Encyclopedia database. Then the co-expression genes relevant to the KLK7 gene were analyzed by the Pearson correlation test. Finally, the impact of KLK7 on clinical prognosis was investigated in distinct subtypes of ovarian cancer patients by UALCAN database and Kaplan–Meier plotter database. RESULTS: It was found that the expression of KLK7 was higher in ovarian cancer compared with other types of cancer, such as gastric cancer and pancreatic cancer. The expression of KLK7 was found to be increased in four various ovarian cancer data sets compared with the healthy tissues. In addition, upregulation of KLK7 expression was associated with age and cancer stage. Moreover, survival analysis revealed that higher KLK7 expression was negatively associated with progression-free survival. CONCLUSION: Knowledge of the expression of KLK7 may be useful for better understanding the outcome in ovarian cancer patients.
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spelling pubmed-77122992020-12-16 Analysis of expression and prognosis of KLK7 in ovarian cancer Chen, Erhua Zhu, Huifang Yang, Yue Wang, Ling Zhang, Jianhua Han, Yonghong Liu, Xiang Open Med (Wars) Research Article BACKGROUND: Ovarian cancer is one of the common malignant tumors in female reproductive organs. Kallikrein-related peptidase (KLK) 7 is a secreted serine peptidase that is related to different cancer. To investigate the expression and significance of KLK7 in ovarian cancer. MATERIALS AND METHODS: The expression of KLK7 in human ovarian cancer was evaluated by Oncomine and Cancer Cell Line Encyclopedia database. Then the co-expression genes relevant to the KLK7 gene were analyzed by the Pearson correlation test. Finally, the impact of KLK7 on clinical prognosis was investigated in distinct subtypes of ovarian cancer patients by UALCAN database and Kaplan–Meier plotter database. RESULTS: It was found that the expression of KLK7 was higher in ovarian cancer compared with other types of cancer, such as gastric cancer and pancreatic cancer. The expression of KLK7 was found to be increased in four various ovarian cancer data sets compared with the healthy tissues. In addition, upregulation of KLK7 expression was associated with age and cancer stage. Moreover, survival analysis revealed that higher KLK7 expression was negatively associated with progression-free survival. CONCLUSION: Knowledge of the expression of KLK7 may be useful for better understanding the outcome in ovarian cancer patients. De Gruyter 2020-09-30 /pmc/articles/PMC7712299/ /pubmed/33336051 http://dx.doi.org/10.1515/med-2020-0139 Text en © 2020 Erhua Chen et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Chen, Erhua
Zhu, Huifang
Yang, Yue
Wang, Ling
Zhang, Jianhua
Han, Yonghong
Liu, Xiang
Analysis of expression and prognosis of KLK7 in ovarian cancer
title Analysis of expression and prognosis of KLK7 in ovarian cancer
title_full Analysis of expression and prognosis of KLK7 in ovarian cancer
title_fullStr Analysis of expression and prognosis of KLK7 in ovarian cancer
title_full_unstemmed Analysis of expression and prognosis of KLK7 in ovarian cancer
title_short Analysis of expression and prognosis of KLK7 in ovarian cancer
title_sort analysis of expression and prognosis of klk7 in ovarian cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712299/
https://www.ncbi.nlm.nih.gov/pubmed/33336051
http://dx.doi.org/10.1515/med-2020-0139
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