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Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers
Vaccines may induce positive non-specific immune responses to other pathogens. This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers. During the first SARS-CoV-2 epidemic wave in Spain,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712321/ https://www.ncbi.nlm.nih.gov/pubmed/33076405 http://dx.doi.org/10.3390/vaccines8040611 |
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author | Martínez-Baz, Iván Trobajo-Sanmartín, Camino Arregui, Irati Navascués, Ana Adelantado, Marta Indurain, Juan Fresán, Ujué Ezpeleta, Carmen Castilla, Jesús |
author_facet | Martínez-Baz, Iván Trobajo-Sanmartín, Camino Arregui, Irati Navascués, Ana Adelantado, Marta Indurain, Juan Fresán, Ujué Ezpeleta, Carmen Castilla, Jesús |
author_sort | Martínez-Baz, Iván |
collection | PubMed |
description | Vaccines may induce positive non-specific immune responses to other pathogens. This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers. During the first SARS-CoV-2 epidemic wave in Spain, between March and May 2020, a cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected. Later in June, 8665 of them were tested for total antibodies in serum. A total of 890 (7.9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected. The adjusted odds ratio between 2019–2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same (1.07; 95% CI, 0.92–1.24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design). Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed an adjusted odds ratio of 0.86 (95% CI, 0.68–1.08). These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection. The development of specific vaccines against SARS-CoV-2 is urgent. |
format | Online Article Text |
id | pubmed-7712321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77123212020-12-04 Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers Martínez-Baz, Iván Trobajo-Sanmartín, Camino Arregui, Irati Navascués, Ana Adelantado, Marta Indurain, Juan Fresán, Ujué Ezpeleta, Carmen Castilla, Jesús Vaccines (Basel) Brief Report Vaccines may induce positive non-specific immune responses to other pathogens. This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2 confirmed infection in a cohort of health workers. During the first SARS-CoV-2 epidemic wave in Spain, between March and May 2020, a cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected. Later in June, 8665 of them were tested for total antibodies in serum. A total of 890 (7.9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected. The adjusted odds ratio between 2019–2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same (1.07; 95% CI, 0.92–1.24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design). Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed an adjusted odds ratio of 0.86 (95% CI, 0.68–1.08). These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection. The development of specific vaccines against SARS-CoV-2 is urgent. MDPI 2020-10-15 /pmc/articles/PMC7712321/ /pubmed/33076405 http://dx.doi.org/10.3390/vaccines8040611 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Martínez-Baz, Iván Trobajo-Sanmartín, Camino Arregui, Irati Navascués, Ana Adelantado, Marta Indurain, Juan Fresán, Ujué Ezpeleta, Carmen Castilla, Jesús Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title | Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title_full | Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title_fullStr | Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title_full_unstemmed | Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title_short | Influenza Vaccination and Risk of SARS-CoV-2 Infection in a Cohort of Health Workers |
title_sort | influenza vaccination and risk of sars-cov-2 infection in a cohort of health workers |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712321/ https://www.ncbi.nlm.nih.gov/pubmed/33076405 http://dx.doi.org/10.3390/vaccines8040611 |
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