The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms

Osteoprotegerin (OPG) appears to be a very promising marker both in the diagnosis of abdominal aortic aneurysms (AAAs) and as a potential target in its treatment. This article presents an overview of the current literature that discusses the role of OPG in the pathogenesis of atherosclerosis and its...

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Autores principales: Migacz, Maciej, Janoska-Gawrońska, Agata, Holecki, Michał, Chudek, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712403/
https://www.ncbi.nlm.nih.gov/pubmed/33336003
http://dx.doi.org/10.1515/med-2020-0046
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author Migacz, Maciej
Janoska-Gawrońska, Agata
Holecki, Michał
Chudek, Jerzy
author_facet Migacz, Maciej
Janoska-Gawrońska, Agata
Holecki, Michał
Chudek, Jerzy
author_sort Migacz, Maciej
collection PubMed
description Osteoprotegerin (OPG) appears to be a very promising marker both in the diagnosis of abdominal aortic aneurysms (AAAs) and as a potential target in its treatment. This article presents an overview of the current literature that discusses the role of OPG in the pathogenesis of atherosclerosis and its potential value as a prognostic factor in AAA. Pharmacological modulation of OPG expression has been considered. In conclusion, it seems that further research designed to assess the relationship between OPG and AAA is needed as this may contribute to improved AAA monitoring and more effective treatment of patients with AAA.
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spelling pubmed-77124032020-12-16 The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms Migacz, Maciej Janoska-Gawrońska, Agata Holecki, Michał Chudek, Jerzy Open Med (Wars) Review Article Osteoprotegerin (OPG) appears to be a very promising marker both in the diagnosis of abdominal aortic aneurysms (AAAs) and as a potential target in its treatment. This article presents an overview of the current literature that discusses the role of OPG in the pathogenesis of atherosclerosis and its potential value as a prognostic factor in AAA. Pharmacological modulation of OPG expression has been considered. In conclusion, it seems that further research designed to assess the relationship between OPG and AAA is needed as this may contribute to improved AAA monitoring and more effective treatment of patients with AAA. De Gruyter 2020-05-26 /pmc/articles/PMC7712403/ /pubmed/33336003 http://dx.doi.org/10.1515/med-2020-0046 Text en © 2020 Maciej Migacz et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Article
Migacz, Maciej
Janoska-Gawrońska, Agata
Holecki, Michał
Chudek, Jerzy
The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title_full The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title_fullStr The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title_full_unstemmed The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title_short The role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
title_sort role of osteoprotegerin in the development, progression and management of abdominal aortic aneurysms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712403/
https://www.ncbi.nlm.nih.gov/pubmed/33336003
http://dx.doi.org/10.1515/med-2020-0046
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