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Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients

We aimed to investigate the prevalence of sarcopenia using new diagnostic criteria and association of sarcopenia with cardiopulmonary function and physical activity (PA) in preoperative lung cancer patients. The data of 614 patients were obtained from the CATCH-LUNG cohort study. Patients were class...

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Autores principales: Kong, Sunga, Shin, Sumin, Lee, Jae Kyung, Lee, Genehee, Kang, Danbee, Cho, Juhee, Kim, Hong Kwan, Zo, Jae Ill, Shim, Young Mog, Park, Hye Yun, Shin, Dong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712435/
https://www.ncbi.nlm.nih.gov/pubmed/33066134
http://dx.doi.org/10.3390/jpm10040166
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author Kong, Sunga
Shin, Sumin
Lee, Jae Kyung
Lee, Genehee
Kang, Danbee
Cho, Juhee
Kim, Hong Kwan
Zo, Jae Ill
Shim, Young Mog
Park, Hye Yun
Shin, Dong Wook
author_facet Kong, Sunga
Shin, Sumin
Lee, Jae Kyung
Lee, Genehee
Kang, Danbee
Cho, Juhee
Kim, Hong Kwan
Zo, Jae Ill
Shim, Young Mog
Park, Hye Yun
Shin, Dong Wook
author_sort Kong, Sunga
collection PubMed
description We aimed to investigate the prevalence of sarcopenia using new diagnostic criteria and association of sarcopenia with cardiopulmonary function and physical activity (PA) in preoperative lung cancer patients. The data of 614 patients were obtained from the CATCH-LUNG cohort study. Patients were classified into three groups—normal (n = 520), pre-sarcopenia (n = 60, low skeletal muscle mass index only), and sarcopenia (n = 34, low SMI and strength). Cardiopulmonary function was measured using the 6-min walk test (6MWT), and PA was objectively measured using a wearable device. The adjusted odds ratio (aOR) for a <400-m distance in 6MWT was 3.52 (95% confidence interval (CI) 1.34–9.21) and 6.63 (95% CI 2.25–19.60) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. The aOR (95% CI) for <5000 steps/day was 1.64 (0.65–4.16) and 4.20 (1.55–11.38) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. In conclusion, the prevalence of pre-sarcopenia and sarcopenia was 9.8% and 5.5%, respectively, among preoperative lung cancer patients. Cardiopulmonary function and physical activity were significantly lower in the pre-sarcopenia and sarcopenia groups than in the normal group. Patients with sarcopenia had more robust findings, suggesting the importance of muscle strength and mass.
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spelling pubmed-77124352020-12-04 Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients Kong, Sunga Shin, Sumin Lee, Jae Kyung Lee, Genehee Kang, Danbee Cho, Juhee Kim, Hong Kwan Zo, Jae Ill Shim, Young Mog Park, Hye Yun Shin, Dong Wook J Pers Med Article We aimed to investigate the prevalence of sarcopenia using new diagnostic criteria and association of sarcopenia with cardiopulmonary function and physical activity (PA) in preoperative lung cancer patients. The data of 614 patients were obtained from the CATCH-LUNG cohort study. Patients were classified into three groups—normal (n = 520), pre-sarcopenia (n = 60, low skeletal muscle mass index only), and sarcopenia (n = 34, low SMI and strength). Cardiopulmonary function was measured using the 6-min walk test (6MWT), and PA was objectively measured using a wearable device. The adjusted odds ratio (aOR) for a <400-m distance in 6MWT was 3.52 (95% confidence interval (CI) 1.34–9.21) and 6.63 (95% CI 2.25–19.60) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. The aOR (95% CI) for <5000 steps/day was 1.64 (0.65–4.16) and 4.20 (1.55–11.38) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. In conclusion, the prevalence of pre-sarcopenia and sarcopenia was 9.8% and 5.5%, respectively, among preoperative lung cancer patients. Cardiopulmonary function and physical activity were significantly lower in the pre-sarcopenia and sarcopenia groups than in the normal group. Patients with sarcopenia had more robust findings, suggesting the importance of muscle strength and mass. MDPI 2020-10-13 /pmc/articles/PMC7712435/ /pubmed/33066134 http://dx.doi.org/10.3390/jpm10040166 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kong, Sunga
Shin, Sumin
Lee, Jae Kyung
Lee, Genehee
Kang, Danbee
Cho, Juhee
Kim, Hong Kwan
Zo, Jae Ill
Shim, Young Mog
Park, Hye Yun
Shin, Dong Wook
Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title_full Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title_fullStr Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title_full_unstemmed Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title_short Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients
title_sort association between sarcopenia and physical function among preoperative lung cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712435/
https://www.ncbi.nlm.nih.gov/pubmed/33066134
http://dx.doi.org/10.3390/jpm10040166
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