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Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)

Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and...

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Autores principales: Zanella, Beatrice, Boccalini, Sara, Bonito, Benedetta, Del Riccio, Marco, Manzi, Federico, Tiscione, Emilia, Bonanni, Paolo, Bechini, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712445/
https://www.ncbi.nlm.nih.gov/pubmed/33053851
http://dx.doi.org/10.3390/vaccines8040599
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author Zanella, Beatrice
Boccalini, Sara
Bonito, Benedetta
Del Riccio, Marco
Manzi, Federico
Tiscione, Emilia
Bonanni, Paolo
Bechini, Angela
author_facet Zanella, Beatrice
Boccalini, Sara
Bonito, Benedetta
Del Riccio, Marco
Manzi, Federico
Tiscione, Emilia
Bonanni, Paolo
Bechini, Angela
author_sort Zanella, Beatrice
collection PubMed
description Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and compare the obtained results to a previous survey conducted in 2005–2006. Methods: A qualitative measurement of anti-rubella antibodies was performed on 165 sera using the enzyme-linked immunosorbent Assay (ELISA). The anamnestic and vaccination status was also collected. Results: Our study highlighted a very high rubella seroprevalence (85–100%) in our enrolled population. In the vaccinated group (153/165), 98.7% of them were positive to rubella antibodies. Conclusions: Our study showed the highest seroprevalence rate reached in the province of Florence for rubella in the last 15 years, thanks to the several successful vaccination campaigns promoted in the Tuscany region. Our findings in pediatric and adolescent subjects are a key factor in preventing CRS in adult life, specifically in childbearing women. Thus, the set goal will be to keep the awareness about the vaccination for this preventable disease high.
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spelling pubmed-77124452020-12-04 Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS) Zanella, Beatrice Boccalini, Sara Bonito, Benedetta Del Riccio, Marco Manzi, Federico Tiscione, Emilia Bonanni, Paolo Bechini, Angela Vaccines (Basel) Article Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and compare the obtained results to a previous survey conducted in 2005–2006. Methods: A qualitative measurement of anti-rubella antibodies was performed on 165 sera using the enzyme-linked immunosorbent Assay (ELISA). The anamnestic and vaccination status was also collected. Results: Our study highlighted a very high rubella seroprevalence (85–100%) in our enrolled population. In the vaccinated group (153/165), 98.7% of them were positive to rubella antibodies. Conclusions: Our study showed the highest seroprevalence rate reached in the province of Florence for rubella in the last 15 years, thanks to the several successful vaccination campaigns promoted in the Tuscany region. Our findings in pediatric and adolescent subjects are a key factor in preventing CRS in adult life, specifically in childbearing women. Thus, the set goal will be to keep the awareness about the vaccination for this preventable disease high. MDPI 2020-10-12 /pmc/articles/PMC7712445/ /pubmed/33053851 http://dx.doi.org/10.3390/vaccines8040599 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zanella, Beatrice
Boccalini, Sara
Bonito, Benedetta
Del Riccio, Marco
Manzi, Federico
Tiscione, Emilia
Bonanni, Paolo
Bechini, Angela
Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title_full Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title_fullStr Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title_full_unstemmed Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title_short Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)
title_sort rubella seroprevalence boost in the pediatric and adolescent population of florence (italy) as a preventive strategy for congenital rubella syndrome (crs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712445/
https://www.ncbi.nlm.nih.gov/pubmed/33053851
http://dx.doi.org/10.3390/vaccines8040599
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